Outcome of a drug-eluting stent in longer below-the-knee lesions in patients with critical limb ischemia

被引:6
作者
Bosiers, Michel J. [1 ,2 ]
Deloose, Koen [4 ]
Peeters, Patrick [4 ]
Torsello, Giovanni [1 ,2 ]
Zeller, Thomas [5 ]
Scheinert, Dierk [6 ]
Schmidt, Andrej [7 ]
Maene, Lieven [7 ]
Keirse, Koen [8 ]
Varcoe, Ramon [9 ]
Bosiers, Marc [3 ]
机构
[1] Univ Munster, Dept Vasc & Endovasc Surg, Hohenzollernring 72, DE-48145 Munster, Germany
[2] St Franziskus Hosp, Dept Vasc Surg, Munster, Germany
[3] St Blasius Univ Hosp, Dept Vasc Surg, Dendermonde, Belgium
[4] Imelda Hosp, Dept Vasc Surg, Bonheiden, Belgium
[5] Bad Krozingen Heart Ctr, Dept Angiol, Bad Krozingen, Germany
[6] Univ Leipzig, Fac Med, Dept Intervent Angiol, Leipzig, Germany
[7] OLV Clin Aalst, Dept Cardiovasc & Thorac Surg, Aalst, Belgium
[8] Heilig Hart Reg Hosp, Dept Vasc Surg, Tienen, Belgium
[9] Prince Wales Hosp, Dept Surg, Sydney, NSW, Australia
关键词
Critical limb ischemia; Popliteal artery; Peripheral arterial disease; Drug-eluting stents; BARE-METAL STENTS; PACLITAXEL-COATED BALLOON; INFRAPOPLITEAL ARTERIES; ANGIOPLASTY; DISEASE; REVASCULARIZATION; METAANALYSIS; PTA;
D O I
10.23736/S0021-9509.16.09546-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: The superiority of drug eluting stents versus bare metal stents or balloon angioplasty in the treatment of patients with critical limb ischemia and infrapopliteal lesions has been established. However, only shorter lesions were evaluated. This study was designed to evaluate the immediate arid long-term (up to 12 months) outcome of the Xience PrimeTM Everolimus-Eluting Coronary Stent System (Abbott Vascular) in a controlled, prospective, multi-center investigation for long lesions up to 10 cm. METHODS: All patients with critical limb ischemia and long infrapopliteal lesions between 30 and 100 mm, who met the inclusion criteria, were included in this study. The primary endpoint was primary patency at 12 months, defined as absence of restenosis (>50% stenosis) or occlusion based on quantitative analysis of contrast angiography. RESULTS: Between August 2011 and October 2013, 60 patients were enrolled in this study with a mean lesion length of 47.40 25.06 mm (range 2-100 mm). The primary patency rate at 12 months was 75.4%. Freedom from target lesion revascularization was 84.9%. The amputation rate was rare (94.4% freedom from amputation). At the 12-month follow-up time point, a total of 36 out of 42 (85.7%) patients improved in their Rutherford classification by at least 1 class. CONCLUSIONS: The use of everolimus-eluting stents in longer infrapopliteal lesions in the treatment of critical limb ischemia is safe and effective with a comparable primary patency, freedom from target lesion revascularization and amputation free survival as in short lesions.
引用
收藏
页码:49 / 54
页数:6
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