Ly6d-L, a cell surface ligand for mouse Ly6d

被引：22
作者：
Apostolopoulos, J [1 ]
McKenzie, IFC [1 ]
Sandrin, MS [1 ]
机构：
[1] Austin & Repatriat Med Ctr, Austin Res Inst, Mol Immunogenet & Transplantat Lab, Heidelberg, Vic 3084, Australia
来源：
IMMUNITY | 2000年 / 12卷 / 02期
关键词：
D O I：
10.1016/S1074-7613(00)80175-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The mouse Ly6 gene family encodes proteins found in lymphocytes and other cells. Some are involved in cell activation; no ligands have been found. A ligand for Ly6d (ThB) was identified on lymphocytes using microspheres loaded with Ly6d and the cDNA isolated from a spleen/thymus library by panning on Ly6d. The Ly6d ligand (Ly6d-L) is a nonglycosylated protein of 9 kDa of broad distribution, rich in cysteine, with no discernable transmembrane sequence. Its N and C termini are on the cell surface, where it associates with a 30 kDa protein. Ly6d-L is homologous with an EGF repeat of Notch.
引用
收藏
页码：223 / 232
页数：10
相关论文
共 33 条
  • [1] Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily
    Adermann, K
    Wattler, F
    Wattler, S
    Heine, G
    Meyer, M
    Forssmann, WG
    Nehls, M
    [J]. PROTEIN SCIENCE, 1999, 8 (04) : 810 - 819
  • [2] APELLA E, 1994, FEBS LETT, V231, P1
  • [3] Identification of mouse Ly6H and its expression in normal tissue
    Apostolopoulos, J
    Chisholm, LJ
    Sandrin, MS
    [J]. IMMUNOGENETICS, 1999, 49 (11-12) : 987 - 990
  • [4] Interleukin-1 receptor antagonist: Characterisation of its gene expression in rabbit tissues and large-scale expression in eucaryotic cells using a baculovirus expression system
    Apostolopoulos, J
    Ross, S
    Davenport, P
    Matsukawa, A
    Yoshinaga, M
    Tipping, PG
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 199 (01) : 27 - 35
  • [5] OVEREXPRESSED LY-6A.2 MEDIATES CELL-CELL ADHESION BY BINDING A LIGAND EXPRESSED ON LYMPHOID-CELLS
    BAMEZAI, A
    ROCK, KL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (10) : 4294 - 4298
  • [6] BAMEZAI A, 1995, J IMMUNOL, V154, P4233
  • [7] BARCLAY AN, 1997, LEUCOCYTE ANTIGEN FA, P2
  • [8] THE HUMAN E48 ANTIGEN, HIGHLY HOMOLOGOUS TO THE MURINE LY-6 ANTIGEN THB, IS A GPI-ANCHORED MOLECULE APPARENTLY INVOLVED IN KERATINOCYTE CELL-CELL ADHESION
    BRAKENHOFF, RH
    GERRETSEN, M
    KNIPPELS, EMC
    VANDIJK, M
    VANESSEN, H
    WEGHUIS, DO
    SINKE, RJ
    SNOW, GB
    VANDONGEN, GAMS
    [J]. JOURNAL OF CELL BIOLOGY, 1995, 129 (06) : 1677 - 1689
  • [9] Campbell ID, 1998, IMMUNOL REV, V163, P11
  • [10] ECHHARDT LA, 1980, IMMUNOGENETICS, V11, P275
1234