Ly6d-L, a cell surface ligand for mouse Ly6d

被引：22

作者：

Apostolopoulos, J ^{[1
]}

McKenzie, IFC ^{[1
]}

Sandrin, MS ^{[1
]}

机构：

[1] Austin & Repatriat Med Ctr, Austin Res Inst, Mol Immunogenet & Transplantat Lab, Heidelberg, Vic 3084, Australia

来源：

IMMUNITY | 2000年 / 12卷 / 02期

关键词：

D O I：

10.1016/S1074-7613(00)80175-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mouse Ly6 gene family encodes proteins found in lymphocytes and other cells. Some are involved in cell activation; no ligands have been found. A ligand for Ly6d (ThB) was identified on lymphocytes using microspheres loaded with Ly6d and the cDNA isolated from a spleen/thymus library by panning on Ly6d. The Ly6d ligand (Ly6d-L) is a nonglycosylated protein of 9 kDa of broad distribution, rich in cysteine, with no discernable transmembrane sequence. Its N and C termini are on the cell surface, where it associates with a 30 kDa protein. Ly6d-L is homologous with an EGF repeat of Notch.

引用

页码：223 / 232

页数：10

共 33 条

[1] Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily [J].