Scalarane-Based Sesterterpenoid RCE-Protease Inhibitors Isolated from the Indonesian Marine Sponge Carteriospongia foliascens

被引：24

作者：

Williams, David E. ^{[1
,5
]}

Hollander, Irwin ^{[2
]}

Feldberg, Larry ^{[2
]}

Frommer, Eileen ^{[2
]}

Mallon, Robert ^{[2
]}

Tahir, Akbar ^{[3
]}

van Soest, Rob ^{[4
]}

Andersen, Raymond J. ^{[1
,5
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] Wyeth Ayerst Res, Oncol & Immunol Div, Pearl River, NY 10965 USA

[3] Univ Hasanuddin, Dept Marine Sci, Ujung Pandang 90245, Indonesia

[4] Univ Amsterdam, Dept Coelenterates & Porifera, Zool Museum, NL-1090 AT Amsterdam, Netherlands

[5] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 06期

关键词：

PHYLLOSPONGIA;

D O I：

10.1021/np900042r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new 20,24-bishomo-25-norscalaranes, compounds 1 and 2, and two new and two known 20,24-bishomoscalaranes, compounds 3-6, have been isolated from the Indonesian marine sponge Carteriospongia foliascens. The structures of 1-6 were determined by spectroscopic analysis. Compounds 1 and 3-6 inhibit RCE-protease activity.

引用

页码：1106 / 1109

页数：4

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