A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials

被引：260

作者：

Meng, Huan ^{[1
]}

Xia, Tian ^{[1
]}

George, Saji ^{[1
,3
]}

Nel, Andre E. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Ctr Environm Impact Nanotechnol, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Nanotoxicol Training & Res Program, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA USA

来源：

ACS NANO | 2009年 / 3卷 / 07期

基金：

美国国家科学基金会;

关键词：

OXIDATIVE STRESS; PARTICULATE POLLUTANTS; ENVIRONMENTAL-IMPACT; COPPER NANOPARTICLES; PULMONARY RESPONSES; OXIDE NANOPARTICLES; CARBON-NANOTUBES; ZINC-OXIDE; TOXICITY; HEALTH;

D O I：

10.1021/nn9005973

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rate of expansion of nanomaterials calls for the consideration of appropriate toxicological paradigms in the safety assessment of nanomaterials. We advocate a predictive toxicological paradigm for the assessment of nanomaterial hazards. The predictive toxicological approach is defined as establishing and using mechanisms and pathways of injury at a cellular and molecular level to prioritize screening for adverse biological effects and health outcomes in vivo. Specifically as it relates to nanomaterials, a predictive approach has to consider the physicochemical properties of the material that leads to molecular or cellular injury and also has to be valid in terms of disease pathogenesis in whole organisms.

引用

页码：1620 / 1627

页数：8

共 43 条

[1] High content screening applied to large-scale cell biology [J].

Abraham, VC ;

Taylor, DL ;

Haskins, JR .

TRENDS IN BIOTECHNOLOGY, 2004, 22 (01) :15-22

[2] Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans [J].

Abraham, Vivek C. ;

Towne, Danli L. ;

Waring, Jeffrey E. ;

Warrior, Usha ;

Burns, David J. .

JOURNAL OF BIOMOLECULAR SCREENING, 2008, 13 (06) :527-537

[3]

[Anonymous], Nanotechnology Consumer Product Inventory

[4] Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress [J].

Araujo, Jesus A. ;

Barajas, Berenice ;

Kleinman, Michael ;

Wang, Xuping ;

Bennett, Brian J. ;

Gong, Ke Wei ;

Navab, Mohamad ;

Harkema, Jack ;

Sioutas, Constantinos ;

Lusis, Aldons J. ;

Nel, Andre E. .

CIRCULATION RESEARCH, 2008, 102 (05) :589-596

[5] Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells [J].

AshaRani, P. V. ;

Mun, Grace Low Kah ;

Hande, Manoor Prakash ;

Valiyaveettil, Suresh .

ACS NANO, 2009, 3 (02) :279-290

[6] Interaction of hemoglobin and copper nanoparticles: implications in hemoglobinopathy [J].

Bhattacharya, Jaydeep ;

Choudhuri, Utpal ;

Siwach, Omprakash ;

Sen, Prasenjit ;

Dasgupta, Anjan Kr. .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2006, 2 (03) :191-199

[7] A tale of opportunities, uncertainties, and risks [J].

Borm, Paul J. A. ;

Berube, David .

NANO TODAY, 2008, 3 (1-2) :56-59

[8] Acute toxicological effects of copper nanoparticles in vivo [J].

Chen, Z ;

Meng, HA ;

Xing, GM ;

Chen, CY ;

Zhao, YL ;

Jia, GA ;

Wang, TC ;

Yuan, H ;

Ye, C ;

Zhao, F ;

Chai, ZF ;

Zhu, CF ;

Fang, XH ;

Ma, BC ;

Wan, LJ .

TOXICOLOGY LETTERS, 2006, 163 (02) :109-120

[9] Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO2 Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population [J].

Chen, Zhen ;

Meng, Huan ;

Xing, Gengmei ;

Yuan, Hui ;

Zhao, Feng ;

Liu, Ru ;

Chang, Xuelin ;

Gao, Xueyun ;

Wang, Tiancheng ;

Jia, Guang ;

Ye, Chang ;

Chai, Zhifang ;

Zhao, Yuliang .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (23) :8985-8992

[10] Toxicology - Transforming environmental health protection [J].

Collins, Francis S. ;

Gray, George M. ;

Bucher, John R. .

SCIENCE, 2008, 319 (5865) :906-907

← 1 2 3 4 5 →