Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence

被引：20
作者：
Huang, Zheng [1 ]
Shi, Songsheng [2 ]
Qiu, Haixia [3 ]
Li, Desheng [4 ]
Zou, Jian [1 ]
Hu, Shaoshan [5 ]
机构：
[1] Fujian Normal Univ, MOE Key Lab OptoElect Sci & Technol Med, 8 Shangsan Rd, Fuzhou 350007, Peoples R China
[2] Fujian Med Univ, Union Hosp, Dept Neurosurg, 29 Xinquan Rd, Fuzhou 350001, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, 28 Fuxing Rd, Beijing 100039, Peoples R China
[4] Acad Mil Med Sci, Affiliated Hosp, Dept Neurosurg, 8 Dongda Ave, Beijing 100071, Peoples R China
[5] Harbin Med Univ, Affiliated Hosp 2, Dept Neurosurg, 246 Xuefu Rd, Harbin 150001, Peoples R China
来源：
NEUROPHOTONICS | 2017年 / 4卷 / 01期
基金：
中国国家自然科学基金;
关键词：
fluorescence; quantification; aminolevulinic acid; protoporphyrin IX; fluorescence-guided resection; brain tumor; HIGH-GRADE GLIOMAS; 5-AMINOLEVULINIC ACID; QUANTITATIVE FLUORESCENCE; PHOTODYNAMIC THERAPY; MALIGNANT GLIOMAS; SURGERY; CANCER; EXCITATION; MARKERS;
D O I：
10.1117/1.NPh.4.1.011011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion. This review will highlight the current progress in PpIX-mediated FGR and discuss technical challenges in intraoperative quantification of intracellular PpIX fluorescence during FGR of brain tumor. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
引用
收藏
页数：5
相关论文
共 33 条
  • [31] δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy
    Valdes, Pablo A.
    Kim, Anthony
    Brantsch, Marco
    Niu, Carolyn
    Moses, Ziev B.
    Tosteson, Tor D.
    Wilson, Brian C.
    Paulsen, Keith D.
    Roberts, David W.
    Harris, Brent T.
    [J]. NEURO-ONCOLOGY, 2011, 13 (08) : 846 - 856
  • [32] Noninvasive measurement of fluorophore concentration in turbid media with a simple fluorescence/reflectance ratio technique
    Weersink, R
    Patterson, MS
    Diamond, K
    Silver, S
    Padgett, N
    [J]. APPLIED OPTICS, 2001, 40 (34) : 6389 - 6395
  • [33] 5-Aminolevulinic Acid Induced Fluorescence Is a Powerful Intraoperative Marker for Precise Histopathological Grading of Gliomas with Non-Significant Contrast-Enhancement
    Widhalm, Georg
    Kiesel, Barbara
    Woehrer, Adelheid
    Traub-Weidinger, Tatjana
    Preusser, Matthias
    Marosi, Christine
    Prayer, Daniela
    Hainfellner, Johannes A.
    Knosp, Engelbert
    Wolfsberger, Stefan
    [J]. PLOS ONE, 2013, 8 (10):
1234