Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence

被引：20
作者：
Huang, Zheng [1 ]
Shi, Songsheng [2 ]
Qiu, Haixia [3 ]
Li, Desheng [4 ]
Zou, Jian [1 ]
Hu, Shaoshan [5 ]
机构：
[1] Fujian Normal Univ, MOE Key Lab OptoElect Sci & Technol Med, 8 Shangsan Rd, Fuzhou 350007, Peoples R China
[2] Fujian Med Univ, Union Hosp, Dept Neurosurg, 29 Xinquan Rd, Fuzhou 350001, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, 28 Fuxing Rd, Beijing 100039, Peoples R China
[4] Acad Mil Med Sci, Affiliated Hosp, Dept Neurosurg, 8 Dongda Ave, Beijing 100071, Peoples R China
[5] Harbin Med Univ, Affiliated Hosp 2, Dept Neurosurg, 246 Xuefu Rd, Harbin 150001, Peoples R China
来源：
NEUROPHOTONICS | 2017年 / 4卷 / 01期
基金：
中国国家自然科学基金;
关键词：
fluorescence; quantification; aminolevulinic acid; protoporphyrin IX; fluorescence-guided resection; brain tumor; HIGH-GRADE GLIOMAS; 5-AMINOLEVULINIC ACID; QUANTITATIVE FLUORESCENCE; PHOTODYNAMIC THERAPY; MALIGNANT GLIOMAS; SURGERY; CANCER; EXCITATION; MARKERS;
D O I：
10.1117/1.NPh.4.1.011011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion. This review will highlight the current progress in PpIX-mediated FGR and discuss technical challenges in intraoperative quantification of intracellular PpIX fluorescence during FGR of brain tumor. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
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页数：5
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