The full spectrum of human naive T cells

被引：174

作者：

van den Broek, Theo ^{[1
,2
,3
,4
]}

Borghans, Jose A. M. ^{[1
]}

van Wijk, Femke ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Lab Translat Immunol, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

[3] Harvard Med Sch, Program Cellular & Mol Med, Boston Childrens Hosp, Boston, MA USA

[4] Harvard Med Sch, Dept Pediat, Boston, MA USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2018年 / 18卷 / 06期

关键词：

RECENT THYMIC EMIGRANTS; RECEPTOR EXCISION CIRCLE; SEVERE COMBINED IMMUNODEFICIENCY; HUMAN PERIPHERAL-BLOOD; UMBILICAL-CORD BLOOD; MEMORY STEM-CELLS; TCR REPERTOIRE; CD4+T CELLS; IN-VIVO; LYMPHOCYTE-ACTIVATION;

D O I：

10.1038/s41577-018-0001-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic output and prior infections. However, there is increasing evidence that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Current strategies to identify naive T cells should be adjusted to take this heterogeneity into account. Here, we provide an integrated, revised view of the naive T cell compartment and discuss its implications for healthy ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation.

引用

页码：363 / 373

页数：11

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