Experimental pulmonary contusion: Review of the literature and description of a new porcine model

被引:47
作者
Cohn, SM
Zieg, PM
机构
[1] Sect. of Trauma/Surg. Critical Care, Yale University, School of Medicine, New Haven, CT
[2] Sect. of Trauma/Surg. Critical Care, Yale School of Medicine, New Haven, CT 06520
关键词
pulmonary contusion; traumatic lung injury; resuscitation; hemorrhagic shock;
D O I
10.1097/00005373-199609000-00036
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
In the setting of pulmonary contusion, massive crystalloid resuscitation of hemorrhagic shock may promote increased lung water leading to stiffer lungs and ultimately culminating in adult respiratory distress syndrome. The emergence of fluids that enable the clinician to resuscitate the bleeding trauma victim by using minimal fluid volumes offers new avenues of investigation for resuscitation of traumatic lung injury. Unfortunately, there has been very little experimental work in the area of pulmonary contusion in the past 15 years. We describe a new porcine model for experimental traumatic lung injury that appears to replicate the clinical scenario.
引用
收藏
页码:565 / 571
页数:7
相关论文
共 43 条
[1]   MECHANISMS OF PULMONARY TRAUMA - AN EXPERIMENTAL STUDY [J].
BORDER, JR ;
HOPKINSON, BR ;
SCHENK, WG .
JOURNAL OF TRAUMA, 1968, 8 (01) :47-+
[2]  
BREWER LA, 1946, ANN SURG, V1233, P343
[3]  
BURFORD TH, 1945, J THORAC SURG, V146, P415
[4]   Pathological changes produced in animals by depth charges [J].
Cameron, GR ;
Short, RHD ;
Wakeley, CPG .
BRITISH JOURNAL OF SURGERY, 1942, 30 (117) :49-64
[5]  
CASLEYSMITH JR, 1976, BRIT J EXP PATHOL, V57, P487
[6]   VARIABLES AFFECTING OUTCOME IN BLUNT CHEST TRAUMA - FLAIL CHEST VS PULMONARY CONTUSION [J].
CLARK, GC ;
SCHECTER, WP ;
TRUNKEY, DD .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1988, 28 (03) :298-304
[7]  
Clark S. L., 1943, SURG GYNECOL OBSTET, V77, P403
[8]   PROPAGATION OF A HIGH EXPLOSIVE AIR SHOCK WAVE THROUGH DIFFERENT PARTS OF AN ANIMAL BODY [J].
CLEMEDSON, CJ ;
PETTERSSON, H .
AMERICAN JOURNAL OF PHYSIOLOGY, 1956, 184 (01) :119-126
[9]  
COHN SM, 1995, J TRAUMA, V392, P210
[10]   EFFECTS OF CONTUSION AND FLAIL CHEST ON PULMONARY PERFUSION AND OXYGEN-EXCHANGE [J].
CRAVEN, KD ;
OPPENHEIMER, L ;
WOOD, LDH .
JOURNAL OF APPLIED PHYSIOLOGY, 1979, 47 (04) :729-737