Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody

被引：30
|
作者：
Cho, Ki Joon [1 ,2 ]
Schepens, Bert [1 ,2 ]
Moonens, Kristof [3 ,4 ]
Deng, Lei [1 ,2 ]
Fiers, Walter [1 ,2 ]
Remaut, Han [3 ,4 ]
Saelens, Xavier [1 ,2 ]
机构：
[1] VIB, Ctr Med Biotechnol, Ghent, Belgium
[2] Univ Ghent, Dept Biomed Mol Biol, B-9000 Ghent, Belgium
[3] VIB, Struct & Mol Microbiol, Struct Biol Res Ctr, Brussels, Belgium
[4] Vrije Univ Brussel, Struct Biol Brussels, Brussels, Belgium
来源：
JOURNAL OF VIROLOGY | 2016年 / 90卷 / 01期
关键词：
MONOCLONAL-ANTIBODY; NEUTRALIZING ANTIBODY; HUMAN RHINOVIRUS; PEPTIDE ANTIGEN; M2; PROTEIN; COMPLEX; ECTODOMAIN; EPITOPE; HIV-1; SITE;
D O I：
10.1128/JVI.02105-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal beta-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.
引用
收藏
页码：611 / 615
页数：5
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