Biological Effect of Gas Plasma Treatment on CO2 Gas Foaming/Salt Leaching Fabricated Porous Polycaprolactone Scaffolds in Bone Tissue Engineering

被引：30

作者：

Bak, Tae-Yeong ^{[1
]}

Kook, Min-Suk ^{[2
]}

Jung, Sang-Chul ^{[3
]}

Kim, Byung-Hoon ^{[1
]}

机构：

[1] Chosun Univ, Sch Dent, Dept Dent Mat, Kwangju 501759, South Korea

[2] Chonnam Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Kwangju 500757, South Korea

[3] Sunchon Natl Univ, Dept Environm Engn, Jeonnam 540742, Suncheon, South Korea

来源：

JOURNAL OF NANOMATERIALS | 2014年 / 2014卷

关键词：

SURFACE MODIFICATION; OSTEOGENIC DIFFERENTIATION; DISCHARGE PLASMA; PORE-SIZE; POLYMER; ADHESION; BIOCOMPATIBILITY; PROLIFERATION;

D O I：

10.1155/2014/657542

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Porous polycaprolactone (PCL) scaffolds were fabricated by using the CO2 gas foaming/salt leaching process and then PCL scaffolds surface was treated by oxygen or nitrogen gas plasma in order to enhance the cell adhesion, spreading, and proliferation. The PCL and NaCl were mixed in the ratios of 3 : 1. The supercritical CO2 gas foaming process was carried out by solubilizing CO2 within samples at 50 degrees C and 8 MPa for 6 hr and depressurization rate was 0.4 MPa/s. The oxygen or nitrogen plasma treated porous PCL scaffolds were prepared at discharge power 100 W and 10 mTorr for 60 s. The mean pore size of porous PCL scaffolds showed 427.89 mu m. The gas plasma treated porous PCL scaffolds surface showed hydrophilic property and the enhanced adhesion and proliferation of MC3T3-E1 cells comparing to untreated porous PCL scaffolds. The PCL scaffolds produced from the gas foaming/salt leaching and plasma surface treatment are suitable for potential applications in bone tissue engineering.

引用

页数：6

共 31 条

[1] Surface modifications by gas plasma control osteogenic differentiation of MC3T3-E1 cells [J].

Barradas, Ana M. C. ;

Lachmann, Kristina ;

Hlawacek, Gregor ;

Frielink, Cathelijne ;

Truckenmoller, Roman ;

Boerman, Otto C. ;

van Gastel, Raoul ;

Garritsen, Henk ;

Thomas, Michael ;

Moroni, Lorenzo ;

van Blitterswijk, Clemens ;

de Boer, Jan .

ACTA BIOMATERIALIA, 2012, 8 (08) :2969-2977

[2] Efficacy of glow discharge gas plasma treatment as a surface modification process for three-dimensional poly (D,L-lactide) scaffolds [J].

Chim, H ;

Ong, JL ;

Schantz, JT ;

Hutmacher, DW ;

Agrawal, CM .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 65A (03) :327-335

[3] Atmospheric RF plasma effects on the film adhesion property [J].

Chung, YM ;

Jung, MJ ;

Han, JG ;

Lee, MW ;

Kim, YM .

THIN SOLID FILMS, 2004, 447 :354-358

[4] Characterization of microcellular biodegradable polymeric foams produced from supercritical carbon dioxide solutions [J].

Cotugno, S ;

Di Maio, E ;

Mensitieri, G ;

Iannace, S ;

Roberts, GW ;

Carbonell, RG ;

Hopfenberg, HB .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2005, 44 (06) :1795-1803

[5] The surface chemistry resulting from low-pressure plasma treatment of polystyrene: The effect of residual vessel bound oxygen [J].

Dhayal, Marshal ;

Alexander, Morgan R. ;

Bradley, James W. .

APPLIED SURFACE SCIENCE, 2006, 252 (22) :7957-7963

[6]

Harris LD, 1998, J BIOMED MATER RES, V42, P396, DOI 10.1002/(SICI)1097-4636(19981205)42:3<396::AID-JBM7>3.0.CO

[7]

2-E

[8] Plasma treatment of polymers for surface and adhesion improvement [J].

Hegemann, D ;

Brunner, H ;

Oehr, C .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2003, 208 :281-286

[9]

Ishaug-Riley SL, 1999, BIOMATERIALS, V20, P2245, DOI 10.1016/S0142-9612(99)00155-6

[10] Characterisation of microcellular foams produced from semi-crystalline PCL using supercritical carbon dioxide [J].

Jenkins, M. J. ;

Harrison, K. L. ;

Silva, M. M. C. G. ;

Whitaker, M. J. ;

Shakesheff, K. M. ;

Howdle, S. M. .

EUROPEAN POLYMER JOURNAL, 2006, 42 (11) :3145-3151

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