Development of nifedipine-loaded albumin microspheres using a statistical factorial design

被引：7

作者：

Chuo, WH ^{[1
]}

Tsai, TR ^{[1
]}

Hsu, SH ^{[1
]}

Cham, TM ^{[1
]}

机构：

[1] KAOHSIUNG MED COLL,SCH PHARM,KAOHSIUNG 807,TAIWAN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 134卷 / 1-2期

关键词：

nifedipine; microspheres; bovine serum albumin; factorial design; sustained release;

D O I：

10.1016/0378-5173(95)04429-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nifedipine-loaded albumin microspheres were prepared by a chemical cross-linking method to develop a sustained-release form. The qualities of the nifedipine-loaded albumin microsphere products were affected by several variables. In this study, the effects on the percentage of nifedipine incorporated into albumin microspheres of four different variables (i.e. drug/albumin ratio, amount of glutaraldehyde, amount of sodium dodecyl sulfate and stirring speed) at two levels were studied according to a factorial design of experiments.

引用

页码：247 / 251

页数：5

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