Development of nifedipine-loaded albumin microspheres using a statistical factorial design

被引：7
|
作者：
Chuo, WH [1 ]
Tsai, TR [1 ]
Hsu, SH [1 ]
Cham, TM [1 ]
机构：
[1] KAOHSIUNG MED COLL,SCH PHARM,KAOHSIUNG 807,TAIWAN
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 134卷 / 1-2期
关键词：
nifedipine; microspheres; bovine serum albumin; factorial design; sustained release;
D O I：
10.1016/0378-5173(95)04429-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nifedipine-loaded albumin microspheres were prepared by a chemical cross-linking method to develop a sustained-release form. The qualities of the nifedipine-loaded albumin microsphere products were affected by several variables. In this study, the effects on the percentage of nifedipine incorporated into albumin microspheres of four different variables (i.e. drug/albumin ratio, amount of glutaraldehyde, amount of sodium dodecyl sulfate and stirring speed) at two levels were studied according to a factorial design of experiments.
引用
收藏
页码：247 / 251
页数：5
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