Gas chromatography-mass spectrometry determination of morphine and codeine in blood as their propionic esters

被引：8
|
作者：
Melent'ev, AB [1 ]
机构：
[1] Chelyabinsk Reg Bur Forens Med, Chelyabinsk 454076, Medgorodok, Russia
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2004年 / 59卷 / 06期
关键词：
D O I：
10.1023/B:JANC.0000030880.72908.85
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A gas-chromatographic separation procedure with mass-spectrometric detection was developed for the detection of opiates in whole blood and the quantitative determination of morphine and codeine as their propionic esters. The detection limit for morphine and codeine in blood was 0.02 mug/mL. The analytical range was 0.05-2.0 mug/mL. The maximum intraseries relative errors were 15.6 and 11.2% for concentrations of 0.05 and 1.0 mug/mL, respectively. The interseries relative errors were no higher than 8 and 3% for concentrations of 0.05 and 1.0 mug/mL, respectively. The procedure is intended for forensic chemical analysis in cases of opiate poisoning.
引用
收藏
页码：566 / 570
页数：5
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