Serum copper to zinc ratio: Relationship with aging and health status

被引：171

作者：

Malavolta, Marco ^{[1
]}

Piacenza, Francesco ^{[1
]}

Basso, Andrea ^{[1
]}

Giacconi, Robertina ^{[1
]}

Costarelli, Laura ^{[1
]}

Mocchegiani, Eugenio ^{[1
]}

机构：

[1] Natl Inst Hlth & Sci Aging INRCA, Sci & Technol Res Area, Nutr & Ageing Ctr, I-60100 Ancona, Italy

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2015年 / 151卷

关键词：

Zinc; Copper; Aging; Inflammation; Homeostasis; ACUTE-PHASE RESPONSE; CERULOPLASMIN SYNTHESIS; IRON ACCUMULATION; GROWTH-HORMONE; PLASMA ZINC; IFN-GAMMA; AGE; ALBUMIN; INFLAMMATION; DEFICIENCY;

D O I：

10.1016/j.mad.2015.01.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The serum concentrations of copper (Cu) and zinc (Zn) are strictly regulated by compensatory mechanisms that act to stabilize them within certain ranges of nutritional intake. However, there are mechanisms that are built to decrease serum concentration of Zn and to increase serum concentration of Cu in the presence of inflammatory conditions, so that a common feature of several age-related chronic diseases is an increase of the Cu to Zn ratio (CZr). Although the clinical potential of CZr has been extensively investigated, few authors addressed the mechanisms that mainly contribute to the increase of CZr in serum during aging, which signals drive this change and how cells respond to these changes. This review focuses on this topic and discusses how an increase of CZr during aging could reflect the homeostatic shade from a general systemic "growth and reproduction" status typical of juvenile age to a "repair and maintenance" status that evolved to preserve health status during old age. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：93 / 100

页数：8

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