A facile synthesis of an oxazolo[5,4]pyrimidin-2-one and a pyrimido[5,4][1,3]oxazin-2-one

被引：5

作者：

Dijkstra, Harmen P. ^{[1
]}

Gaulon, Catherine ^{[1
]}

Niculescu-Duvaz, Dan ^{[1
]}

Springer, Caroline J. ^{[1
]}

机构：

[1] Inst Canc Res, Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England

来源：

SYNLETT | 2006年 / 10期

关键词：

pyrimidines; cyclic carbamates; ring-closing; heterocyclic chemistry;

D O I：

10.1055/s-2006-941604

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis is reported for the construction of the five- and six-membered fused carbamate rings of an oxazolo[5,4]pyrimidin-2-one and a pyrimido[5,4][1,3]oxazin-2-one, respectively. The method utilises a controlled two-step procedure in which a reactive p-nitrophenylcarbamate intermediate ring closes upon treatment with base, affording the bicyclic pyrimidine-carbamate scaffolds in good yields.

引用

页码：1519 / 1522

页数：4

共 17 条

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