Percutaneous Mitral Valve Edge-to-Edge Repair In-Hospital Results and 1-Year Follow-Up of 628 Patients of the 2011-2012 Pilot European Sentinel Registry

被引：361

作者：

Nickenig, Georg ^{[1
]}

Estevez-Loureiro, Rodrigo ^{[2
]}

Franzen, Olaf ^{[3
]}

Tamburino, Corrado ^{[4
]}

Vanderheyden, Marc ^{[5
]}

Luescher, Thomas F. ^{[6
]}

Moat, Neil ^{[7
]}

Price, Susanna ^{[8
]}

Dall'Ara, Gianni ^{[2
]}

Winter, Reidar ^{[9
]}

Corti, Roberto ^{[6
]}

Grasso, Carmelo ^{[4
]}

Snow, Thomas M. ^{[2
]}

Jeger, Raban ^{[10
]}

Blankenberg, Stefan ^{[11
]}

Settergren, Magnus ^{[9
]}

Tiroch, Klaus ^{[12
]}

Balzer, Jan ^{[13
]}

Petronio, Anna Sonia ^{[14
]}

Buettner, Heinz-Joachim ^{[15
]}

Ettori, Federica ^{[16
]}

Sievert, Horst ^{[17
]}

Fiorino, Maria Giovanna ^{[18
]}

Claeys, Marc ^{[19
]}

Ussia, Gian Paolo ^{[20
]}

Baumgartner, Helmut ^{[21
]}

Scandura, Salvatore ^{[4
]}

Alamgir, Farqad ^{[22
]}

Keshavarzi, Freidoon ^{[22
]}

Colombo, Antonio ^{[23
]}

Maisano, Francesco ^{[24
]}

Ebelt, Henning ^{[25
]}

Aruta, Patrizia ^{[4
]}

Lubos, Edith ^{[11
]}

Plicht, Bjoern ^{[26
]}

Schueler, Robert ^{[1
]}

Pighi, Michele ^{[2
]}

Di Mario, Carlo ^{[2
]}

机构：

[1] Univ Bonn, Dept Internal Med & Cardiol Pneumol, Bonn, Germany

[2] Royal Brompton Hosp, NIHR Biomed Res Unit, Dept Cardiol, London SW3 6NP, England

[3] Rigshosp, Dept Cardiol, DK-2100 Copenhagen, Denmark

[4] Ferrarotto Hosp, Dept Cardiol, Catania, Italy

[5] Onze Lieve Vrouw Hosp, Dept Cardiol, Aalst, Belgium

[6] Univ Zurich Hosp, Dept Cardiol, CH-8091 Zurich, Switzerland

[7] Royal Brompton Hosp, NIHR Biomed Res Unit, Dept Cardiac Surg, London SW3 6NP, England

[8] Royal Brompton Hosp, NIHR Biomed Res Unit, Intens Care Unit, London SW3 6NP, England

[9] Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden

[10] Univ Basel Hosp, Dept Cardiol, CH-4031 Basel, Switzerland

[11] Univ Herzzentrum Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany

[12] Helios Klinikum Wuppertal, Dept Cardiol, Wuppertal, Germany

[13] Univ Klinikum Dusseldorf, Dept Cardiol, Dusseldorf, Germany

[14] Azienda Osped Univ Pisana, Cardiothorac & Vasc Dept, Cardiac Catheterizat Lab, Pisa, Italy

[15] Univ Herzzentrum Freiburg, Dept Cardiol & Angiol 2, Bad Krozingen, Germany

[16] Spedali Civili Brescia, Cardiothorac Dept, Brescia, Italy

[17] CardioVasc Centrum Frankfurt, Dept Cardiol & Vasc Med, Frankfurt, Germany

[18] Osped Civ ARNAS, Dept Cardiol, Palermo, Italy

[19] Univ Hosp Antwerpen, Dept Cardiol, Edegem, Belgium

[20] Policlin Tor Vergata, Dept Cardiol, Rome, Italy

[21] Univ Klinikum Munster, Dept Cardiol & Angiol, Munster, Germany

[22] Castle Hill Hosp, Dept Cardiol, Cottingham, England

[23] Univ San Raffaele, Dept Cardiol, Milan, Italy

[24] Univ San Raffaele, Dept Cardiovasc Surg, Milan, Italy

[25] Univ Klinikum Halle Saale, Dept Cardiol, Halle, Germany

[26] Univ Clin Essen, Dept Cardiol, Essen, Germany

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 64卷 / 09期

关键词：

MitraClip; mitral regurgitation; percutaneous mitral valve repair; registry; SURGICAL-RISK PATIENTS; REGURGITATION; THERAPY; MITRACLIP(R); OUTCOMES; REDUCTION; SURGERY; SYSTEM; ANNULOPLASTY; REPLACEMENT;

D O I：

10.1016/j.jacc.2014.06.1166

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND The use of transcatheter mitral valve repair (TMVR) has gained widespread acceptance in Europe, but data on immediate success, safety, and long-term echocardiographic follow-up in real-world patients are still limited. OBJECTIVES The aim of this multinational registry is to present a real-world overview of TMVR use in Europe. METHODS The Transcatheter Valve Treatment Sentinel Pilot Registry is a prospective, independent, consecutive collection of individual patient data. RESULTS A total of 628 patients (mean age 74.2 +/- 9.7 years, 63.1% men) underwent TMVR between January 2011 and December 2012 in 25 centers in 8 European countries. The prevalent pathogenesis was functional mitral regurgitation (FMR) (n = 452 [72.0%]). The majority of patients (85.5%) were highly symptomatic (New York Heart Association functional class III or higher), with a high logistic EuroSCORE (European System for Cardiac Operative Risk Evaluation) (20.4 +/- 16.7%). Acute procedural success was high (95.4%) and similar in FMR and degenerative mitral regurgitation (p = 0.662). One clip was implanted in 61.4% of patients. In-hospital mortality was low (2.9%), without significant differences between groups. The estimated 1-year mortality was 15.3%, which was similar for FMR and degenerative mitral regurgitation. The estimated 1-year rate of rehospitalization because of heart failure was 22.8%, significantly higher in the FMR group (25.8% vs. 12.0%, p[log-rank] = 0.009). Paired echocardiographic data from the 1-year follow-up, available for 368 consecutive patients in 15 centers, showed a persistent reduction in the degree of mitral regurgitation at 1 year (6.0% of patients with severe mitral regurgitation). CONCLUSIONS This independent, contemporary registry shows that TMVR is associated with high immediate success, low complication rates, and sustained 1-year reduction of the severity of mitral regurgitation and improvement of clinical symptoms. (C) 2014 by the American College of Cardiology Foundation.

引用

页码：875 / 884

页数：10

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