Systematic Evaluation of Diagnostic Delay in Pediatric Inflammatory Bowel Disease

被引：16

作者：

Schoepfer, Alain M. ^{[1
,2
]}

Vavricka, Stephan ^{[3
,4
]}

Safroneeva, Ekaterina ^{[5
]}

Fournier, Nicolas ^{[2
,6
]}

Manser, Christine ^{[4
]}

Frei, Pascal ^{[4
]}

Deltenre, Pierre ^{[1
,2
]}

Rogler, Gerhard ^{[4
]}

Straumann, Alex ^{[7
]}

Ezri, Jessica ^{[2
,8
]}

Nydegger, Andreas ^{[2
,8
]}

Braegger, Christian ^{[9
,10
]}

机构：

[1] CHU Vaudois, Div Gastroenterol & Hepatol, Rue Bugnon 46, CH-1011 Lausanne, Switzerland

[2] Univ Lausanne, Lausanne, Switzerland

[3] Triemli Municipal Hosp, Div Gastroenterol & Hepatol, Zurich, Switzerland

[4] Univ Zurich Hosp, Div Gastroenterol & Hepatol, Zurich, Switzerland

[5] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

[6] CHU Vaudois, Inst Social & Prevent Med, Lausanne, Switzerland

[7] Univ Basel Hosp, Div Gastroenterol & Hepatol, Basel, Switzerland

[8] CHU Vaudois, Div Pediat Gastroenterol & Nutr, Lausanne, Switzerland

[9] Univ Childrens Hosp Zurich, Div Gastroenterol & Nutr, Zurich, Switzerland

[10] Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2017年 / 64卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

Crohn disease; diagnostic delay; pediatric inflammatory bowel diseases; ulcerative colitis; CROHNS-DISEASE; ULCERATIVE-COLITIS; POPULATION; DURATION; CHILDREN; COHORT;

D O I：

10.1097/MPG.0000000000001238

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We evaluated the diagnostic delay (time from first symptoms to diagnosis) in 100 pediatric patients with Crohn disease (CD) and 75 patients with ulcerative colitis (UC). Median (interquartile range) diagnostic delay in patients with CD was 4 (2-8) (range 0-82) months compared with 2 (1-7) (range 0-52) months in patients with UC (P = 0.003). The time interval from first physician visit to inflammatory bowel disease diagnosis was longer in patients with CD and UC when compared to the time interval from symptom onset to first physician visit (CD: median 3 vs 1 months, P < 0.001; UC: median 2 vs 0 months, P < 0.001). No specific risk factors were identified for the length of diagnostic delay. Measures should be taken to reduce diagnostic delay.

引用

页码：245 / 247

页数：3

共 16 条

[1] Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease [J].

Etchevers, Maria Josefina ;

Aceituno, Montserrat ;

Sans, Miguel .

WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (36) :5512-5518

[2] Presenting symptoms and diagnostic lag in children with inflammatory bowel disease [J].

Heikenen, JB ;

Werlin, SL ;

Brown, CW ;

Balint, JP .

INFLAMMATORY BOWEL DISEASES, 1999, 5 (03) :158-160

[3] The Diagnostic Accuracy of Fecal Calprotectin During the Investigation of Suspected Pediatric Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis [J].

Henderson, Paul ;

Anderson, Niall H. ;

Wilson, David C. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (05) :637-645

[4] Response to infliximab is related to disease duration in paediatric Crohn's disease [J].

Lionetti, P ;

Bronzini, F ;

Salvestrini, C ;

Bascietto, C ;

Canani, RB ;

Dé Angelis, GL ;

Guariso, G ;

Martelossi, S ;

Papadatou, B ;

Barabino, A .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 18 (04) :425-431

[5] Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted county, Minnesota, 1940-2000 [J].

Loftus, Conor G. ;

Loftus, Edward V., Jr. ;

Harmsen, W. Scott ;

Zinsmeister, Alan R. ;

Tremaine, William J. ;

Melton, L. Joseph, III ;

Sandborn, William J. .

INFLAMMATORY BOWEL DISEASES, 2007, 13 (03) :254-261

[6] Early Inflammatory Bowel Disease: Different Treatment Response to Specific or All Medications? [J].

Markowitz, James .

DIGESTIVE DISEASES, 2009, 27 (03) :358-365

[7] Incidence and clinical presentation of IBD in children: Comparison between prospective and retrospective data in a selected Norwegian population [J].

Perminow, Gori ;

Frigessi, Arnoldo ;

Rydning, Andreas ;

Nakstad, Britt ;

Vatn, Morten H. .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2006, 41 (12) :1433-1439

[8] A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from South-Eastern Norway, 2005-07, showing increased incidence in Crohn's disease [J].

Perminow, Gori ;

Brackmann, Stephan ;

Lyckander, Lars G. ;

Franke, Andre ;

Borthne, Arne ;

Rydning, Andreas ;

Aamodt, Geir ;

Schreiber, Stefan ;

Vatn, Morten H. .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2009, 44 (04) :446-456

[9]

Pimentel M, 2000, AM J GASTROENTEROL, V95, P3458

[10] Cohort Profile: The Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) [J].

Pittet, Valerie ;

Juillerat, Pascal ;

Mottet, Christian ;

Felley, Christian ;

Ballabeni, Pierluigi ;

Burnand, Bernard ;

Michetti, Pierre ;

Vader, John-Paul .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2009, 38 (04) :922-931

← 1 2 →