Divergent Syntheses of 2-Aminonicotinonitriles and Pyrazolines by Copper-Catalyzed Cyclization of Oxime Ester

被引：133
作者：
Wu, Qifan
Zhang, Yan
Cui, Sunliang [1 ]
机构：
[1] Zhejiang Univ, Inst Mat Med, Hangzhou 310058, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 05期
基金：
中国国家自然科学基金;
关键词：
ORIENTED ORGANIC-SYNTHESIS; H BOND ACTIVATION; EFFICIENT SYNTHESIS; PARALLEL SYNTHESIS; DRUG DISCOVERY; CONSTRUCTION; ANTAGONISTS; AMINATION; ALDEHYDES; PYRIDINES;
D O I：
10.1021/ol500094w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed cyclization of an oxime ester toward divergent heterocycle synthesis is reported. Oxime ester serves as an enamine precursor to cyclize with malononitrile and aldehydes for access to 2-aminonicotinonitriles in a one-pot reaction, while cyclizing with N-sulfonylimines leads to synthesis of pyrazolines.
引用
收藏
页码：1350 / 1353
页数：4
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