Interceptive [4+1] Annulation of in Situ Generated 1,2-Diaza-1,3-dienes with Diazo Esters: Direct Access to Substituted Mono-, Bi-, and Tricyclic 4,5-Dihydropyrazoles

被引：76

作者：

Attanasi, Orazio A. ^{[1
]}

De Crescentini, Lucia ^{[1
]}

Favi, Gianfranco ^{[1
]}

Mantellini, Fabio ^{[1
]}

Mantenuto, Serena ^{[1
]}

Nicolini, Simona ^{[1
]}

机构：

[1] Univ Urbino Carlo Bo, Dept Biomol Sci, Sect Organ Chem & Organ Nat Cpds, I-61029 Urbino, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 17期

关键词：

CHLORIDE-CATALYZED REACTION; ELECTRON-RICH CARBENES; DIELS-ALDER REACTIONS; SULFUR YLIDES; CARBON-MONOXIDE; ENANTIOSELECTIVE SYNTHESIS; STRAIGHTFORWARD FORMATION; NECROPTOSIS INHIBITORS; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS;

D O I：

10.1021/jo5016097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In situ derived acylic and cyclic 1,2-diaza-1,3dienes (DDs) were engaged in interceptive [4 + 1] annulation strategy with diazo esters (DEs). The catalytic activity of inexpensive copper(1) chloride allows the direct synthesis of mono-, hi-, and tricyclic 4,5-dihydropyrazole-5-carboxylic acid derivatives in a process that circumvents the use of an anhydrous and inert atmosphere.

引用

页码：8331 / 8338

页数：8

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