Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a humanized mouse model

被引:0
|
作者
Brady, Jamie L. [1 ,2 ]
Sutherland, Robyn M. [1 ,2 ]
Hancock, Manuela [1 ]
Kitsoulis, Susie [3 ]
Lahoud, Mireille H. [3 ,4 ]
Phillips, Peta M. [5 ]
Hawthorne, Wayne J. [5 ]
d'Apice, Anthony J. [6 ,7 ]
Cowan, Peter J. [6 ,7 ]
Harrison, Leonard C. [1 ,2 ]
O'Connell, Philip J. [5 ]
Lew, Andrew M. [1 ,2 ,8 ]
机构
[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia
[3] Burnet Inst, Melbourne, Vic, Australia
[4] Monash Univ, Dept Immunol, Melbourne, Vic 3004, Australia
[5] Univ Sydney, Westmead Hosp, Westmead Millennium Inst, Ctr Transplant & Renal Res, Westmead, NSW 2145, Australia
[6] Univ Melbourne, Dept Med, Parkville, Vic 3052, Australia
[7] St Vincents Hosp, Immunol Res Ctr, Fitzroy, Vic 3065, Australia
[8] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia
关键词
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
282
引用
收藏
页码:S23 / S23
页数:1
相关论文
共 50 条
  • [41] Low Dose IL-2 and Rapamycin Protects Against Human Islet Allograft Rejection and Inhibit IFN-γ Producing T Cells in a Humanized Diabetic Mouse Model
    Hu, M.
    Hawthorne, W.
    Nan, H.
    Wu, J.
    Liuwantara, D.
    Qian, Y.
    Yi, S.
    Alexander, S.
    O'Connell, P.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 : 354 - 354
  • [42] T-CELL DEPLETION OF BONE-MARROW FOR CLINICAL MARROW ALLOGRAFTING - OPTIMALIZATION OF CONDITIONS FOR DEPLETION BY ANTI-CD2 AND ANTI-CD8 MONOCLONAL-ANTIBODIES WITH RABBIT COMPLEMENT, AND FOR DETECTION OF RESIDUAL T-CELL CONTENT
    COOLEY, MA
    FARRELLY, H
    OFLAHERTY, E
    BIGGS, JC
    ATKINSON, K
    PATHOLOGY, 1987, 19 (02) : 131 - 136
  • [43] Knock-in of anti-CD2 and human thrombomodulin transgenes into pig GGTA1 using CRISPR/Cas9
    Salvaris, Evelyn
    Fisicaro, Nella
    Vasiliev, Ivan
    McIlfatrick, Stephen
    Nottle, Mark
    Brady, Jamie
    Lew, Andrew
    Cowan, Peter
    TRANSPLANTATION, 2016, 100 (07) : S237 - S237
  • [44] ACTIVATION OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS WITH SINGLE ANTI-CD2 MONOCLONAL-ANTIBODIES
    STOHL, W
    CLINICAL RESEARCH, 1990, 38 (02): : A431 - A431
  • [45] A new humanized HLA transgenic mouse model of multiple seleirosis expressing class II on mouse CD4 T cells
    Mangalam, Ashutosh
    Rodriguez, Moses
    David, Chella
    HOW DO WE BEST EMPLOY ANIMAL MODELS FOR TYPE 1 DIABETES AND MULTIPLE SCLEROSIS?, 2007, 1103 : 112 - 117
  • [46] Anti-CD2 T cell depletion with two level T cell addback (TCD-AB) in allogeneic bone marrow transplantation (Al-BMT).
    Lee, CK
    Hayashi, M
    Harman, GS
    Hohl, RJ
    Ajram, KA
    Gingrich, RD
    BLOOD, 1995, 86 (10) : 2269 - 2269
  • [47] The Effect of Ex Vivo Preservation and Regulatory T Cells on the Development of Transplant Arteriosclerosis in a Humanized Mouse Model
    Knoefel, A.
    Siemeni, T.
    Ius, F.
    Sommer, W.
    Salman, J.
    Tudorache, I.
    Haverich, A.
    Falk, C.
    Warnecke, G.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 : 718 - 719
  • [48] SUPPRESSOR CELLS GENERATED BY ANTI-CD2 BLOCK THE INDUCTION OF T-CELL-DEPENDENT B-CELL DIFFERENTIATION
    HIROKAWA, M
    GRAY, JD
    WANG, H
    HORWITZ, DA
    FASEB JOURNAL, 1994, 8 (05): : A1014 - A1014
  • [49] Regulatory T Cells and the Effect of Ex Vivo Preservation on the Development of Transplant Arteriosclerosis in a Humanized Mouse Model
    Knoefel, A.
    Siemeni, T.
    Ius, F.
    Avsar, M.
    Hacker, K.
    Salman, J.
    Haverich, A.
    Falk, C.
    Warnecke, G.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2021, 40 (04): : S344 - S344
  • [50] Humanized Mouse Model of Skin Inflammation Is Characterized by Disturbed Keratinocyte Differentiation and Influx of IL-17A Producing T Cells
    de Oliveira, Vivian L.
    Keijsers, Romy R. M. C.
    van de Kerkhof, Peter C. M.
    Seyger, Marieke M. B.
    Fasse, Esther
    Svensson, Lars
    Latta, Markus
    Norsgaard, Hanne
    Labuda, Tord
    Hupkens, Pieter
    van Erp, Piet E. J.
    Joosten, Irma
    Koenen, Hans J. P. M.
    PLOS ONE, 2012, 7 (10):