Parvovirus capsid disorders cholesterol-rich membranes

被引：4
作者：
Pakkanen, Kirsi [1 ]
Kirjavainen, Sanna
Makela, Anna R. [2 ]
Rintanen, Nina
Oker-Blom, Christian
Jalonen, Tuula O.
Vuento, Matti
机构：
[1] Univ Jyvaskyla, Dept Biol & Environm Sci, FIN-40014 Jyvaskyla, Finland
[2] NEXT Biomed Technol NBT Oy, Helsinki, Finland
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 379卷 / 02期
基金：
芬兰科学院;
关键词：
Virus capsid; Membrane disorder; Cholesterol-rich membrane; Di-4-ANEPPDHQ; CANINE PARVOVIRUS; LIPID RAFTS; PHASE-EQUILIBRIA; VIRUS ENTRY; INFECTION; TRANSDUCTION; ENDOCYTOSIS; PROTEINS; VESICLES; SIGNAL;
D O I：
10.1016/j.bbrc.2008.12.116
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this Study canine parvovirus, CPV, was found to induce disorder in DPPC:cholesterol membranes in acidic conditions. This acidicity-induced fluidizing effect is Suggested to originate from the N-terminus of the viral capsid protein VP1. In accordance with the model membrane Studies, a fluidizing effect was seen also in the endosomal membranes during CPV infection implying an important functional role of the fluidization in the endocytic entry of the virus. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：562 / 566
页数：5
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