Aerosol Immunotherapy with or without Cisplatin for metastatic lung cancer non-small cell lung cancer disease: In vivo Study. A more efficient combination

被引：4

作者：

Sapalidis, Konstantinos ^{[1
]}

Zarogoulidis, Paul ^{[2
]}

Pavlidis, Efstathios ^{[1
]}

Laskou, Stella ^{[1
]}

Katsaounis, Athanasios ^{[1
]}

Koulouris, Charilaos ^{[1
]}

Giannakidis, Dimitrios ^{[1
]}

Mantalovas, Stylianos ^{[1
]}

Huang, Haidong ^{[3
]}

Bai, Chong ^{[3
]}

Wen, Yuting ^{[4
]}

Wang, Li ^{[4
]}

Sardeli, Chrysanthi ^{[5
]}

Amaniti, Aikaterini ^{[6
]}

Karapantzos, Ilias ^{[7
]}

Karapantzou, Chrysanthi ^{[7
]}

Hohenforst-Schmidt, Wolfgang ^{[8
]}

Konstantinou, Fotis ^{[9
]}

Kesisoglou, Isaak ^{[1
]}

Benhanseen, Naim ^{[8
]}

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Surg 3, Med Sch, Thessaloniki, Greece

[2] Theageneio Canc Hosp, Oncol Unit, Pulm Dept, Thessaloniki, Greece

[3] Second Mil Med Univ, Changhai Hosp, Dept Resp & Crit Care Med, Shanghai, Peoples R China

[4] Nanjing Med Univ, Affiliated Jiangning Hosp, Dept Resp Dis, Nanjing, Jiangsu, Peoples R China

[5] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Dept Pharmacol & Clin Pharmacol, Thessaloniki, Greece

[6] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Anesthesiol Dept, Med Sch, Thessaloniki, Greece

[7] St Luke Private Hosp, Ear Nose & Throat Dept, Thessaloniki, Greece

[8] Univ Erlangen Nurnberg, HotClin, Dept Cardiol Pulmonol Intens Care Nephrol, Sana Clin Grp Franken, Hof, Germany

[9] Democritus Univ Thrace, Univ Gen Hosp Alexandroupolis, Thorac Surg Dept, Alexandroupolis, Greece

来源：

JOURNAL OF CANCER | 2018年 / 9卷 / 11期

关键词：

lung cancer; aerosol; immunotherapy; NSCLC; nivolumab; ipilimumab; pembrolizumab; programmed death-ligand 1; PERIPHERAL PULMONARY-LESIONS; ENDOBRONCHIAL ULTRASOUND; GENE-THERAPY; EBUS-TBNA; PHASE-II; CHEMOTHERAPY; DIAGNOSIS; TUMORS; COLD; HOT;

D O I：

10.7150/jca.24782

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is the leading cause of cancer death after prostate cancer for males and breast cancer for females. There are novel therapies in the past five years such as; tyrosine kinase inhibitors and most recently in the last two years immunotherapy. Immunotherapy is currently being investigated if it can be administered alone or in combination. Previously we have investigated whether immunotherapy compounds can be produced as aerosols, and in the current study we investigated the safety and efficiency independently of the programmed death-ligand 1. The aerosol administration of both cisplatin and nivolumab is possible. The combination of the two drugs has a synergistic effect and therefore should be considered an option. Time of administration for immunotherapy is also very important.

引用

页码：1973 / 1977

页数：5

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