Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis

被引:35
作者
van Rensburg, S. J.
Kotze, M. J.
Hon, D.
Haug, P.
Kuyler, J.
Hendricks, M.
Botha, J.
Potocnik, F. C. V.
Matsha, T.
Erasmus, R. T.
机构
[1] Natl Hlth Lab Serv, ZA-7505 Tygerberg, South Africa
[2] Univ Stellenbosch, Tygerberg Hosp, ZA-7505 Tygerberg, South Africa
[3] Christiaan Barnard Mem Hosp, Genecare Mol Genet, Cape Town, South Africa
[4] Univ Stellenbosch, Dept Neurol, ZA-7600 Stellenbosch, South Africa
[5] Panorama Medi Clin, Panorama, South Africa
[6] Univ Stellenbosch, Dept Psychiat, ZA-7600 Stellenbosch, South Africa
[7] Univ Stellenbosch, Rehabil Unit, ZA-7600 Stellenbosch, South Africa
基金
英国医学研究理事会;
关键词
multiple sclerosis; myelin regeneration; iron; EDSS; nutrition; homocysteine;
D O I
10.1007/s11011-006-9019-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin B12-methylation pathway. The aim of this study was to determine iron status, folate and homocysteine in MS subjects, and to evaluate the effect on MS symptoms if deficiencies were addressed. Results: In relapsing-remitting MS subjects, serum iron concentration correlated significantly with age at diagnosis (r = 0.49; p = 0.008). In Caucasian female MS subjects, serum iron and ferritin concentrations were significantly lower than in matched controls. In a 6-month pilot study, 12 subjects taking a regimen of nutritional supplements designed to promote myelin regeneration, improved significantly neurologically as measured by the Kurzke EDSS (Total Score means 3.50 to 2.45, 29.9%; p = 0.021). These were significantly improved (P = 0.002) compared to 6 control group patients taking multivitamins (Kurzke Score increased by 13.9% from 4.83 to 5.50). Both groups had significantly reduced homocysteine concentrations at 6 months, suggesting that methylation is necessary but not sufficient for myelin regeneration.
引用
收藏
页码:121 / 137
页数:17
相关论文
共 44 条
  • [1] BADENOCH J, 1959, BRIT J HAEMATOL, V3, P175
  • [2] Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
    Barnett, MH
    Prineas, JW
    [J]. ANNALS OF NEUROLOGY, 2004, 55 (04) : 458 - 468
  • [3] Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats
    Beard, JL
    Wiesinger, JA
    Connor, JR
    [J]. DEVELOPMENTAL NEUROSCIENCE, 2003, 25 (05) : 308 - 315
  • [4] CLAUSEN J, 1993, ACTA NEUROL SCAND, V87, P461
  • [5] Connor JR, 1996, GLIA, V17, P83, DOI 10.1002/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO
  • [6] 2-7
  • [7] COX EV, 1959, LANCET, V2, P998
  • [8] DAVIDSON WMB, 1955, LANCET, V2, P639
  • [9] MULTIPLE-SCLEROSIS IN BLACK SOUTH-AFRICANS AND ZIMBABWEANS
    DEAN, G
    BHIGJEE, AIG
    BILL, PLA
    FRITZ, V
    CHIKANZA, IC
    THOMAS, JEP
    LEVY, LF
    SAFFER, D
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1994, 57 (09) : 1064 - 1069
  • [10] DEVILLIERS JNP, 2006, IN PRESS METABOLIC B, V21