Intelligent cell-based therapies for cancer and autoimmune disorders

被引:12
作者
Chen, Rui [1 ]
Jing, Ji [1 ]
Siwko, Stefan [1 ]
Huang, Yun [2 ,3 ]
Zhou, Yubin [1 ,3 ]
机构
[1] Texas A&M Univ, Ctr Translat Canc Res, Inst Biosci & Technol, Houston, TX 77030 USA
[2] Texas A&M Univ, Ctr Epigenet & Dis Prevent, Inst Biosci & Technol, Houston, TX 77030 USA
[3] Texas A&M Univ, Coll Med, Dept Translat Med Sci, Houston, TX 77030 USA
关键词
T-CELLS; TARGETED THERAPY; IMMUNOTHERAPY; SWITCH;
D O I
10.1016/j.copbio.2020.08.012
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Synthetic biology, when combined with immunoengineering (designated synthetic immunology), has enabled the invention of an arsenal of genetically encoded synthetic devices and systems to reprogram cells for therapeutic purposes. The engineered intelligent cells can serve as 'living' drugs to treat a wide range of human diseases including cancer, disorders of the immune system, and infectious diseases. As the most successful example, cells of the immune system engineered with chimeric antigen receptors (CARs) have shown curative potentials for the treatment of hematological malignancies. We present herein emerging approaches of designing smart CARs to improve their safety, specificity and efficacy in cellular immunotherapy, and describe latest advances in applying CAR-engineered immune cells to target cancer and autoimmune diseases.
引用
收藏
页码:207 / 216
页数:10
相关论文
共 50 条
[41]   Natural Killer cell-Based cancer immunotherapies: From immune evasion to Promising targeted cellular therapies [J].
Hofer, Erhard ;
Koehl, Ulrike .
FRONTIERS IN IMMUNOLOGY, 2017, 8
[42]   Emerging trends in cell-based therapies: contemporary advances and ethical considerations in translational neurosurgical oncology [J].
Abikenari, Matthew ;
Liu, Justin ;
Ha, Joseph H. ;
Annagiri, Shreyas ;
Himic, Vratko ;
Medikonda, Ravi ;
Kim, Lily ;
Choi, John ;
Lim, Michael .
JOURNAL OF NEURO-ONCOLOGY, 2025,
[43]   Dendritic cell-based cancer immunotherapy for pancreatic cancer [J].
Li, Wei ;
Song, Xiujun ;
Yu, Huijie ;
Zhang, Manze ;
Li, Fengsheng ;
Cao, Cheng ;
Jiang, Qisheng .
ARAB JOURNAL OF GASTROENTEROLOGY, 2018, 19 (01) :1-6
[44]   Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers [J].
Olivia M. Turk ;
Ryan C. Woodall ;
Margarita Gutova ;
Christine E. Brown ;
Russell C. Rockne ;
Jennifer M. Munson .
Drug Delivery and Translational Research, 2021, 11 :2448-2467
[45]   Emerging therapies for small cell lung cancer [J].
Yang, Sen ;
Zhang, Zhe ;
Wang, Qiming .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12 (1)
[46]   Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers [J].
Turk, Olivia M. ;
Woodall, Ryan C. ;
Gutova, Margarita ;
Brown, Christine E. ;
Rockne, Russell C. ;
Munson, Jennifer M. .
DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2021, 11 (06) :2448-2467
[47]   Optimizing dendritic cell-based immunotherapy for cancer [J].
Zhong, Hua ;
Shurin, Michael R. ;
Han, Baohui .
EXPERT REVIEW OF VACCINES, 2007, 6 (03) :333-345
[48]   NK cell-based therapeutics for lung cancer [J].
Pockley, A. Graham ;
Vaupel, Peter ;
Multhoff, Gabriele .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2020, 20 (01) :23-33
[49]   Natural killer cell-based immunotherapy for cancer [J].
Ma, Shoubao ;
Yu, Jianhua ;
Caligiuri, Michael A. .
JOURNAL OF IMMUNOLOGY, 2025, 214 (07) :1444-1456
[50]   Enhancing Delivery of Small-Molecule- and Cell-Based Therapies for Ovarian Cancer Using Advanced Delivery Strategies [J].
O'Dwyer, Joanne ;
O'Cearbhaill, Roisin E. ;
Wylie, Robert ;
O'Mahony, Saoirse ;
O'Dwyer, Michael ;
Duffy, Garry P. ;
Dolan, Eimear B. .
ADVANCED THERAPEUTICS, 2020, 3 (11)