The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

被引：720

作者：

Takenawa, Tadaomi ^{[1
]}

Suetsugu, Shiro ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Biochem, Minato Ku, Tokyo 1088639, Japan

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 01期

关键词：

D O I：

10.1038/nrm2069

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Wiskott-Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein (WAVE) family proteins are scaffolds that link upstream signals to the activation of the ARP2/3 complex, leading to a burst of actin polymerization. ARP2/3-complex-mediated actin polymerization is crucial for the reorganization of the actin cytoskeleton at the cell cortex for processes such as cell movement, vesicular trafficking and pathogen infection. Large families of membrane-binding proteins were recently found to interact with WASP and WAVE family proteins, therefore providing a new layer of membrane-dependent regulation of actin polymerization.

引用

页码：37 / 48

页数：12

共 150 条

[1] Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth [J].

Abe, T ;

Kato, M ;

Miki, H ;

Takenawa, T ;

Endo, T .

JOURNAL OF CELL SCIENCE, 2003, 116 (01) :155-168

[2]

ALDRICH RA, 1954, PEDIATRICS, V13, P133

[3] WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation [J].

Antón, IM ;

de la Fuente, MA ;

Sims, TN ;

Freeman, S ;

Ramesh, N ;

Hartwig, JH ;

Dustin, ML ;

Geha, RS .

IMMUNITY, 2002, 16 (02) :193-204

[4] Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton [J].

Aronheim, A ;

Broder, YC ;

Cohen, A ;

Fritsch, A ;

Belisle, B ;

Abo, A .

CURRENT BIOLOGY, 1998, 8 (20) :1125-1128

[5] The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms [J].

Aspenström, P .

EXPERIMENTAL CELL RESEARCH, 2004, 298 (02) :485-498

[6] The WASP-Binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor [J].

Aspenström, P .

EXPERIMENTAL CELL RESEARCH, 2002, 279 (01) :21-33

[7] Two GTPases, cdc42 and rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome [J].

Aspenstrom, P ;

Lindberg, U ;

Hall, A .

CURRENT BIOLOGY, 1996, 6 (01) :70-75

[8] Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells [J].

Banzai, Y ;

Miki, H ;

Yamaguchi, H ;

Takenawa, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (16) :11987-11992

[9] SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development [J].

Bear, JE ;

Rawls, JF ;

Saxe, CL .

JOURNAL OF CELL BIOLOGY, 1998, 142 (05) :1325-1335

[10] Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins [J].

Blanchoin, L ;

Amann, KJ ;

Higgs, HN ;

Marchand, JB ;

Kaiser, DA ;

Pollard, TD .

NATURE, 2000, 404 (6781) :1007-1011

← 1 2 3 4 5 6 7 8 9 10 →