Photonic crystal nanostructures for optical biosensing applications

被引：133

作者：

Dorfner, D. ^{[1
]}

Zabel, T. ^{[1
]}

Hurlimann, T. ^{[1
]}

Hauke, N. ^{[1
]}

Frandsen, L. ^{[2
]}

Rant, U. ^{[1
]}

Abstreiter, G. ^{[1
]}

Finley, J. ^{[1
]}

机构：

[1] Tech Univ Munich, Walter Schottky Inst, D-85748 Garching, Germany

[2] Tech Univ Denmark, DTU Foton, Dept Photon Engn, DK-2800 Lyngby, Denmark

来源：

BIOSENSORS & BIOELECTRONICS | 2009年 / 24卷 / 12期

关键词：

Photonic crystal; Nanocavity; Silicon; Nanostructure; Optical biosensor;

D O I：

10.1016/j.bios.2009.05.014

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We present the design, fabrication and optical investigation of photonic crystal (PhC) nanocavity drop filters for use as optical biosensors. The resonant cavity mode wavelength and Q-factor are studied as a function of the ambient refractive index and as a function of adsorbed proteins (bovine serum albumin) on the sensor surface. Experiments were performed by evanescent excitation of the cavity mode via a PhC waveguide. This in turn is coupled to a ridge waveguide that allows the introduction of a fluid flow cell on a chip. A response of partial derivative lambda/partial derivative c = (4.54 +/- 0.66) x 10(5) nm/M is measured leading to a measured detection limit as good as Delta m = 4.0 +/- 0.6 fg or Delta m/Delta A = (4.9 +/- 0.7) x 10(2) pg/mm(2) in the sensitive area. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：3688 / 3692

页数：5

共 25 条

[1] High-Q photonic nanocavity in a two-dimensional photonic crystal [J].

Akahane, Y ;

Asano, T ;

Song, BS ;

Noda, S .

NATURE, 2003, 425 (6961) :944-947

[2] Silicon-on-insulator based nanopore cavity arrays for lipid membrane investigation [J].

Buchholz, K. ;

Tinazli, A. ;

Kleefen, A. ;

Dorfner, D. ;

Pedone, D. ;

Rant, U. ;

Tampe, R. ;

Abstreiter, G. ;

Tornow, M. .

NANOTECHNOLOGY, 2008, 19 (44)

[3]

Butt H. J., 2013, Physics and Chemistry of Interfaces

[4] Organophosphonate-based PNA-functionalization of silicon nanowires for label-free DNA detection [J].

Cattani-Scholz, Anna ;

Pedone, Daniel ;

Dubey, Manish ;

Neppl, Stefan ;

Nickel, Bert ;

Feulner, Peter ;

Schwartz, Jeffrey ;

Abstreiter, Gerhard ;

Tornow, Marc .

ACS NANO, 2008, 2 (08) :1653-1660

[5] Ultracompact biochemical sensor built with two-dimensional photonic crystal microcavity [J].

Chow, E ;

Grot, A ;

Mirkarimi, LW ;

Sigalas, M ;

Girolami, G .

OPTICS LETTERS, 2004, 29 (10) :1093-1095

[6] Biosensors: recent advances [J].

Collings, AF ;

Caruso, F .

REPORTS ON PROGRESS IN PHYSICS, 1997, 60 (11) :1397-1445

[7] Silicon photonic crystal nanostructures for refractive index sensing [J].

Dorfner, D. F. ;

Huerlimann, T. ;

Zabel, T. ;

Frandsen, L. H. ;

Abstreiter, G. ;

Finley, J. J. .

APPLIED PHYSICS LETTERS, 2008, 93 (18)

[8] Surface plasmon resonance sensors: review [J].

Homola, J ;

Yee, SS ;

Gauglitz, G .

SENSORS AND ACTUATORS B-CHEMICAL, 1999, 54 (1-2) :3-15

[9] Guided modes in photonic crystal slabs [J].

Johnson, SG ;

Fan, SH ;

Villeneuve, PR ;

Joannopoulos, JD ;

Kolodziejski, LA .

PHYSICAL REVIEW B, 1999, 60 (08) :5751-5758

[10] Photonic crystals in the optical regime - past, present and future [J].

Krauss, TF ;

De la Rue, RM .

PROGRESS IN QUANTUM ELECTRONICS, 1999, 23 (02) :51-96

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