Bidirectional and dynamic interaction between the microbiota and therapeutic resistance in pancreatic cancer

被引：16
作者：
Dong, Jia [1 ,2 ,3 ,4 ]
Gao, He-Li [1 ,2 ,3 ,4 ]
Wang, Wen-Quan [1 ,2 ,3 ,4 ]
Yu, Xian-Jun [1 ,2 ,3 ,4 ]
Liu, Liang [1 ,2 ,3 ,4 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Dept Pancreat Surg, 270 Dong An Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
[3] Shanghai Pancreat Canc Inst, Shanghai, Peoples R China
[4] Fudan Univ, Pancreat Canc Inst, Shanghai, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1875卷 / 01期
基金：
上海市自然科学基金; 中国国家自然科学基金; 美国国家科学基金会;
关键词：
Pancreatic cancer; Microbiomes; Immunotherapy; Therapeutic resistance; IRINOTECAN-INDUCED DIARRHEA; GUT MICROBIOTA; INTESTINAL MICROBIOTA; HEPATITIS-B; TUMOR MICROENVIRONMENT; FECAL MICROBIOTA; IMMUNE; HEALTH; BACTERIA; RISK;
D O I：
10.1016/j.bbcan.2020.188484
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic ductal adenocarcinoma is one of the most lethal malignancies and is known for its high resistance and low response to treatment. Cancer treatments can reshape the microbiota and in turn, the microbiota influences the therapeutic efficacy by regulating immune response and metabolism. This crosstalk is bidirectional, heterogeneous, and dynamic. In this review, we elaborated on the interactions between the microbiota and therapeutic resistance in pancreatic ductal adenocarcinoma. Regulating the microbiota in pancreatic tumor microenvironment may not only generate direct anti-cancer but also synergistic effects with other treatments, providing new directions in cancer therapy.
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页数：11
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