Clinical Efficacy of SARS-CoV-2 Vaccination in Hemodialysis Patients

被引：30

作者：

Torres, Ruben ^{[1
,2
]}

Toro, Luis ^{[1
,2
,3
]}

Eugenia Sanhueza, Maria ^{[1
,2
]}

Lorca, Eduardo ^{[1
,4
]}

Ortiz, Mireya ^{[1
,5
]}

Pefaur, Jacqueline ^{[1
,6
]}

Clavero, Rene ^{[1
,7
]}

Machuca, Eduardo ^{[1
,8
]}

Gonzalez, Fernando ^{[4
]}

Herrera, Patricia ^{[1
,4
]}

Mocarquer, Alfredo ^{[1
,9
]}

Frias, Alondra ^{[1
,10
]}

Roessler, Eric ^{[1
,5
]}

Munoz, Carolina ^{[1
,11
]}

Nunez, Miguel ^{[1
,11
]}

Aravena, Cesar ^{[1
,12
]}

Quintana, Enrique ^{[1
,13
]}

Lemus, Juan ^{[1
,14
]}

Lillo, Mario ^{[1
,15
]}

Reynolds, Enrique ^{[1
,4
]}

Morales, Alvaro ^{[1
,4
]}

Pais, Edgard ^{[1
,16
]}

Fiabane, Andrea ^{[1
,6
]}

Parra-Lucares, Alfredo ^{[17
]}

Garrido, Cristian ^{[31
]}

Mendez-Valdes, Gabriel ^{[32
]}

Villa, Eduardo ^{[32
]}

Mansilla, Rodrigo ^{[1
,18
]}

Sotomayor, Germana ^{[1
]}

Gonzalez, Marcela ^{[1
,19
]}

Miranda, Cecilia ^{[1
,20
]}

Briones, Eduardo ^{[1
,21
]}

Gomez, Esteban ^{[1
,22
]}

Mezzano, Sergio ^{[1
,23
]}

Bernales, Waldo ^{[1
,24
]}

Rocca, Ximena ^{[1
,4
]}

Espinoza, Oscar ^{[1
,4
]}

Zuniga, Eric ^{[1
,25
]}

Aragon, Henry ^{[1
,26
]}

Badilla, Marta ^{[1
,27
]}

Valenzuela, Marcela ^{[1
,16
]}

Escobar, Luis ^{[1
,26
]}

Zamora, Daniela ^{[1
,6
]}

Flores, Ivan ^{[1
,28
]}

Tapia, Beatriz ^{[1
,7
]}

Borquez, Tamara ^{[1
,29
]}

Herrera, Patricio ^{[1
,30
]}

机构：

[1] Soc Chilena Nefrol, Fuerza Trabajo Anti COVID 19, Providencia, Chile

[2] Univ Chile, Hosp Clin, Dept Med, Div Nephrol, 999 Santos Dumt St,PO 8380456, Santiago, Chile

[3] Univ Chile, Hosp Clin, Ctr Invest Clin Avanzada, Santiago, Chile

[4] Hosp Salvador, Div Nephrol, Santiago, Chile

[5] Pontificia Univ Catolica Chile, Sch Med, Dept Nephrol, Santiago, Chile

[6] Hosp Barros Luco, Div Nephrol, Santiago, Chile

[7] Hosp Gustavo Fricke, Div Nephrol, Valparaiso, Chile

[8] Fresenius Med Care Chile, Santiago, Chile

[9] Dialisis Gran Ave, Santiago, Chile

[10] Hosp Reg Talca, Div Nephrol, Talca, Chile

[11] Hosp Puerto Montt, Div Nephrol, Puerto Montt, Chile

[12] Dialisis Municipal La Granja, Santiago, Chile

[13] Hosp Padre Hurtado, Div Nephrol, Santiago, Chile

[14] Dialysis Ctr, Santiago, Chile

[15] Ctr Med Dialisis, Santiago, Chile

[16] Complejo Asistencial Sotero del Rio, Div Nephrol, Santiago, Chile

[17] Hosp Clin Univ Chile, Dept Med, Div Crit Care Med, Santiago, Chile

[18] Hosp Clin Magallanes, Div Nephrol, Punta Arenas, Chile

[19] Hosp Mil Santiago, Div Nephrol, Santiago, Chile

[20] CID Serv Integral Salud, Santiago, Chile

[21] Clin Indisa, Div Nephrol, Santiago, Chile

[22] Hosp Clin San Borja Arriaran, Div Nephrol, Santiago, Chile

[23] Univ Austral Chile, Fac Med, Santiago, Chile

[24] Hosp Reg Coyha, Div Nephrol, Coyhaique, Chile

[25] Univ Antofagasta, Hosp Clin, Div Nephrol, Antofagasta, Chile

[26] Hosp San Jose, Div Nephrol, Santiago, Chile

[27] Hosp Puerto Natales, Div Nephrol, Puerto Natales, Chile

[28] Hosp San Juan Dios Cur, Div Nephrol, Curico, Chile

[29] Hosp Clin Reg Dr Guillermo Grant Benavente, Div Nephrol, Concepcion, Chile

[30] Serv Salud Chiloe, Castro, X Region, Chile

[31] Hosp Clin Univ Chile, Dept Radiol, Santiago, Chile

[32] Univ Chile, Fac Med, Santiago, Chile

来源：

KIDNEY INTERNATIONAL REPORTS | 2022年 / 7卷 / 10期

关键词：

COVID-19; epidemiology; hemodialysis; mortality; renal dialysis; SARS-CoV-2; IMMUNE-RESPONSES; COVID-19; INFECTION;

D O I：

10.1016/j.ekir.2022.07.007

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: The COVID-19 pandemic is a global public health problem. Patients with end-stage renal disease on hemodialysis are at a higher risk of infection and mortality than the general population. Worldwide, a vaccination campaign has been developed that has been shown to reduce severe infections and deaths in the general population. However, there are currently limited data on the clinical efficacy of vaccinations in the hemodialysis population. Methods: A national multicenter observational cohort was performed in Chile to evaluate the clinical efficacy of anti-SARS-CoV-2 vaccination in end-stage renal disease patients on chronic hemodialysis from February 2021 to August 2021. In addition, the BNT162b2 (Pfizer-BioNTech) and CoronaVac (Sinovac) vaccines were evaluated. The efficacy of vaccination in preventing SARS-CoV-2 infection, hospitalizations, and deaths associated with COVID-19 was determined. Results: A total of 12,301 patients were evaluated; 10,615 (86.3%) received a complete vaccination (2 doses), 490 (4.0%) received incomplete vaccination, and 1196 (9.7%) were not vaccinated. During followup, 1362 (11.0%) patients developed COVID-19, and 150 died (case fatality rate: 11.0%). The efficacy of the complete vaccination in preventing infection was 18.1% (95% confidence interval [CI]:11.8-23.8%), and prevention of death was 66.0% (95% CI:60.6-70.7%). When comparing both vaccines, BNT162b2 and CoronaVac were effective in reducing infection and deaths associated with COVID-19. Nevertheless, the BNT162b2 vaccine had higher efficacy in preventing infection (42.6% vs. 15.0%) and deaths (90.4% vs. 64.8%) compared to CoronaVac. Conclusion: The results of our study suggest that vaccination against SARS-CoV-2 in patients on chronic hemodialysis was effective in preventing infection and death associated with COVID-19.

引用

页码：2176 / 2185

页数：10

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