A New Iridoid from the Aerial Parts of Hedyotis pilulifera

被引：1

作者：

Nguyen Thi Hoai ^{[1
,2
]}

Ho Viet Duc ^{[1
]}

Nguyen Dinh Quynh Phu ^{[1
]}

Kodama, Takeshi ^{[2
]}

Ito, Takuya ^{[2
]}

Morita, Hiroyuki ^{[2
]}

机构：

[1] Hue Univ, Hue Univ Med & Pharm, Fac Pharm, 06 Ngo Quyen, Hue City, Vietnam

[2] Toyama Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 03期

基金：

日本学术振兴会;

关键词：

Hedyotis pilulifera; 10-Acetylborreriagenin; Iridoid; Antibacterial activity; GLUCOSIDES; GLYCOSIDES; DIFFUSA; RUBIACEAE; LAWSONIAE; STEMS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new iridoid, 10-acetylborreriagenin (1), and five known iridoid glycosides (2-6), were isolated from the aerial parts of Hedyotis pilulifera. Their structures were elucidated by spectral analyses, including 1D- and 2D-NMR, and HR-ESI-MS, and comparisons with the NMR data reported in the literature. The isolated compounds 1-6 were tested against six bacterial species. Among them, 10-acetylborreriagenin (1) showed antibacterial activity against Staphylococcus aureus, with an MIC value of 100 mu g/mL.

引用

页码：365 / 367

页数：3

共 21 条

[1] Anthraquinones from Hedyotis capitellata [J].

Ahmad, R ;

Shaari, K ;

Lajis, NH ;

Hamzah, AS ;

Ismail, NH ;

Kitajima, M .

PHYTOCHEMISTRY, 2005, 66 (10) :1141-1147

[2]

Demirezer LÖ, 2006, TURK J CHEM, V30, P525

[3] Biologically Active Iridoids from Hedyotis diffusa [J].

Ding, Bo ;

Ma, Wei-Wei ;

Dai, Yi ;

Gao, Hao ;

Yu, Yang ;

Tao, Ye ;

Zhong, Yi ;

Yao, Xin-Sheng .

HELVETICA CHIMICA ACTA, 2010, 93 (12) :2488-2494

[4] A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria [J].

Eloff, JN .

PLANTA MEDICA, 1998, 64 (08) :711-713

[5] New Anthraquinone and Iridoid Glycosides from the Stems of Hedyotis hedyotidea [J].

Hu, Xiao-Ping ;

Zhang, Shu-Wei ;

Liu, Shan-Shan ;

Xuan, Li-Jiang .

HELVETICA CHIMICA ACTA, 2011, 94 (04) :675-685

[6]

HUI WH, 1977, PHYTOCHEMISTRY, V16, P1309, DOI 10.1016/S0031-9422(00)94389-9

[7] Iridoid glycosides from Hedyotis corymbosa [J].

Jiang, Wei ;

Kuang, Li-Sha ;

Hou, Ai-Jun ;

Qian, Min ;

Li, Ji-Zong .

HELVETICA CHIMICA ACTA, 2007, 90 (07) :1296-1301

[8]

KIKUCHI T, 1985, CHEM PHARM BULL, V33, P1444

[9] Triterpenoid saponins from Hedyotis nudicaulis [J].

Konishi, M ;

Hano, Y ;

Takayama, M ;

Nomura, T ;

Hamzah, AS ;

Ahmad, RB ;

Jasmani, H .

PHYTOCHEMISTRY, 1998, 48 (03) :525-528

[10] A new acylated flavonol glycoside and antioxidant effects of Hedyotis diffusa [J].

Lu, CM ;

Yang, JJ ;

Wang, PY ;

Lin, CC .

PLANTA MEDICA, 2000, 66 (04) :374-376

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