Targeting the Mitochondrial Protease Clpp Unveils Mitochondrial Vulnerabilities in Multiple Myeloma

被引:1
|
作者
Perini, Tommaso [1 ,2 ]
Oliva, Laura [2 ]
Materozzi, Maria [2 ]
Del Pizzo, Rossella [2 ]
Cassina, Laura [3 ]
Samur, Mehmet K. [4 ]
Orfanelli, Ugo [2 ]
Milan, Enrico [2 ]
Boletta, Alessandra [3 ]
Munshi, Nikhil C. [5 ]
Cenci, Simone [2 ]
机构
[1] IRCCS Osped San Raffaele, Hematol & Bone Marrow Transplantat Unit, Milan, Italy
[2] IRCCS Osped San Raffaele, Div Genet & Cell Biol, Lab Age Related Dis, Milan, Italy
[3] IRCCS San Raffaele Sci Inst, Div Genet & Cell Biol, Milan, Italy
[4] Harvard TH Chan Sch Publ Hlth, Dana Farber Canc Inst, Dept Data Sci, Boston, MA USA
[5] Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA
关键词
D O I
10.1182/blood-2022-164536
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:7072 / 7073
页数:2
相关论文
共 50 条
  • [1] Targeting the mitochondrial protease ClpP unveils novel vulnerabilities in multiple myeloma
    Perini, Tommaso
    Materozzi, Maria
    Del Pizzo, Rossella
    Cassina, Laura
    Samur, Mehmet
    Orfanelli, Ugo
    Milan, Enrico
    Boletta, Alessandra
    Munshi, Nikhil
    Cenci, Simone
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 : S96 - S96
  • [2] Targeting the mitochondrial protease CLPP in Multiple Myeloma
    Perini, Tommaso
    Oliva, Laura
    Materozzi, Maria
    Cassina, Laura
    Samur, Mehmet K.
    Orfanelli, Ugo
    Milan, Enrico
    Boletta, Alessandra
    Munshi, Nikhil C.
    Cenci, Simone
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S95 - S95
  • [3] Mitochondrial protease ClpP is a novel immunogenic vulnerability in multiple myeloma
    Perini, Tommaso
    Zordan, Paola
    Del Pizzo, Rossella
    Oliva, Laura
    Materozzi, Maria
    Samur, Mehmet
    Orfanelli, Ugo
    Milan, Enrico
    Munshi, Nikhil
    Matteo, Bellone
    Cenci, Simone
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S239 - S240
  • [4] The mitochondrial protease ClpP is a promising target for multiple myeloma treatment
    Liu, Xiang
    Gu, Jinlong
    Liu, Song
    Huang, Jingcao
    Li, Linfeng
    Wang, Fangfang
    He, Siyao
    Mi, Ziyue
    Zhang, Yue
    Wen, Jingjing
    Gao, Qianwen
    Yang, Haonan
    Feng, Yu
    Luo, Hongmei
    Zhai, Xinyu
    Zhang, Li
    Zheng, Yuhuan
    Luo, Youfu
    Niu, Ting
    BIOCHEMICAL PHARMACOLOGY, 2025, 236
  • [5] Inhibition of the human mitochondrial ClpP protease as a novel strategy against multiple myeloma
    Patrone, M.
    Di Pisa, F.
    Tosatto, L.
    Swuec, P.
    Perini, T.
    Resnati, M.
    Del Grosso, Erika
    Yudin, A. K.
    Schimmer, A. D.
    Cenci, S.
    Coscia, F.
    Degano, M.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2024, 80
  • [6] Suppression of multiple myeloma by mitochondrial targeting
    Yana Aisen
    Moshe E. Gatt
    Rachel Hertz
    Elia Smeir
    Jacob Bar-Tana
    Scientific Reports, 11
  • [7] Suppression of multiple myeloma by mitochondrial targeting
    Aisen, Yana
    Gatt, Moshe E.
    Hertz, Rachel
    Smeir, Elia
    Bar-Tana, Jacob
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [8] The mitochondrial ClpP protease: from basic principles to drug discovery
    Houry, Walid
    PROTEIN SCIENCE, 2023, 32 (12)
  • [9] The mitochondrial ClpP protease: from basic principles to drug discovery
    Houry, Walid
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 300 (03) : S121 - S121
  • [10] Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity
    Hu, Di
    Sun, Xiaoyan
    Liao, Xudong
    Zhang, Xinwen
    Zarabi, Sara
    Schimmer, Aaron
    Hong, Yuning
    Ford, Christopher
    Luo, Yu
    Qi, Xin
    ACTA NEUROPATHOLOGICA, 2019, 137 (06) : 939 - 960