One-pot synthesis of oxazoles using isocyanide surrogates

被引：24
作者：
El Kaim, Laurent [1 ]
Grimaud, Laurence [1 ]
Schiltz, Aurelie [1 ]
机构：
[1] Ecole Natl Super Tech Avancees, Lab Chim & Procedes, DCSO, UMR 7652, F-75015 Paris, France
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 37期
关键词：
Isocyanide; Oxazole; Alkylation; Silver cyanide; Multicomponent reaction; ALKYL-HALIDES; ISONITRILE;
D O I：
10.1016/j.tetlet.2009.07.001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We wish to present herein a simple one-pot synthesis of 2,5-disubstituted oxazoles, starting from benzyl halides and acyl chlorides. The in Situ formation of isocyanides, followed by the addition of an acyl chloride in the presence of a base leads to the desired oxazoles in good yields. (C) 2009 Published by Elsevier Ltd.
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收藏
页码：5235 / 5237
页数：3
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