Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility

被引：12

作者：

Ben Chaaben, Arij ^{[1
,2
,3
]}

Mariaselvam, Christina ^{[2
]}

Salah, Sofiane ^{[2
]}

Busson, Marc ^{[2
]}

Dulphy, Nicolas ^{[2
,4
]}

Douik, Hayet ^{[1
]}

Ghanem, Abderraouf ^{[1
]}

Boukaouci, Wahid ^{[2
]}

Al Daccak, Reem ^{[2
]}

Mamoghli, Tesnim ^{[1
]}

Harzallah, Latifa ^{[1
]}

Bouassida, Jihene ^{[1
]}

Fortier, Catherine ^{[4
]}

Gritli, Said ^{[1
]}

Ben Hamida, Jeannette

Charron, Dominique ^{[2
,4
]}

Krishnamoorthy, Rajagopal ^{[2
]}

Guemira, Fethi ^{[1
]}

Tamouza, Ryad ^{[2
,4
]}

机构：

[1] Salah Azaiz Inst Canc, Dept Biol Clin, Tunis, Tunisia

[2] St Louis Hosp, INSERM, U940, Paris, France

[3] Sci Univ Tunis, ISBAT, Dept Biochem, Tunis, Tunisia

[4] St Louis Hosp, Jean Dausset Dept Immunol & Immunogenet & LabEx T, Paris, France

来源：

IMMUNOBIOLOGY | 2015年 / 220卷 / 01期

关键词：

Nasopharyngeal carcinoma; Oxidative stress; Nitric oxide; Nitric oxide synthase; Glutathione S-transferases; Polymorphism; Tunisia; NITRIC-OXIDE SYNTHASE; COLORECTAL-CANCER RISK; DNA-DAMAGE; CROSS-TALK; MYOCARDIAL-INFARCTION; GLU298ASP VARIANT; PROSTATE-CANCER; S TRANSFERASES; BREAST-CANCER; EXPRESSION;

D O I：

10.1016/j.imbio.2014.09.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factor. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3-786C allele and -786 CC genotype, NOS3+894T allele and +894 GT+1T genotypes, NOS2-277 G allele and -277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red-ox stress pathway could augment the risk in NPC-susceptible individuals. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：20 / 25

页数：6

共 50 条

[1] Influence of Oxidative Stress-Related Genes on Susceptibility to Fibromyalgia
Rus, Alma
Robles-Fernandez, Inmaculada
Martinez-Gonzalez, Luis Javier
Carmona, Ramon
Alvarez-Cubero, Maria Jesus
NURSING RESEARCH, 2021, 70 (01) : 44 - 50
[2] Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers
Choi, Ji-Yeob
Neuhouser, Marian L.
Barnett, Matt
Hudson, Matthew
Kristal, Alan R.
Thomquist, Mark
King, Irena B.
Goodman, Gary E.
Ambrosone, Christine B.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (06) : 1115 - 1120
[3] Oxidative stress-related gene polymorphisms and susceptibility to Barrett's esophagus
Piazuelo, E
Garcia-Gonzalez, MA
Strunk, M
Alcedo, J
Arenas, J
Ferrandez, A
Jimenez, P
Lanas, A
GASTROENTEROLOGY, 2003, 124 (04) : A633 - A633
[4] Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk
Seibold, Petra
Hein, Rebecca
Schmezer, Peter
Hall, Per
Liu, Jianjun
Dahmen, Norbert
Flesch-Janys, Dieter
Popanda, Odilia
Chang-Claude, Jenny
INTERNATIONAL JOURNAL OF CANCER, 2011, 129 (06) : 1467 - 1476
[5] Polymorphisms in Oxidative Stress-related Genes Modify Environmental Effects on Asthma Exacerbations
Xue, S.
Wang, J.
Li, X.
Meyers, D. A.
Bleecker, E. R.
Ortega, V. E.
Calhoun, W. J.
Chung, K.
Castro, M.
Jarjour, N. N.
Erzurum, S. C.
Israel, E.
Levy, B. D.
Fahy, J. V.
Moore, W. C.
Mauger, D.
Denlinger, L. C.
Woodruff, P.
Wenzel, S. E.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207
[6] Seven oxidative stress-related genes predict the prognosis of hepatocellular carcinoma
Miao, Chen
He, Xiao
Chen, Gang
Kahlert, Ulf D.
Yao, Chenchen
Shi, Wenjie
Su, Dongming
Hu, Liang
Zhang, Zhihong
AGING-US, 2023, 15 (24): : 15050 - 15063
[7] Identification of biomarkers associated with oxidative stress-related genes in postmenopausal osteoporosis
Liu, Dan
Hu, Zhijun
Tang, Zhanying
Li, Pan
Yuan, Weina
Li, Fangfang
Chen, Qian
CELLULAR AND MOLECULAR BIOLOGY, 2023, 69 (06) : 186 - 192
[8] Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes
Kim, Jin Hee
Lee, Mee-Ri
Hong, Yun-Chul
ENVIRONMENTAL RESEARCH, 2016, 147 : 324 - 330
[9] Association of oxidative stress-related genes with miscarriage
Mashkina, E.
Kovalenko, K.
Bukreeva, A.
EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 879 - 880
[10] Identification and analysis of oxidative stress-related genes in endometriosis
Xie, Chengmao
Lu, Chang
Lv, Na
Kong, Weimin
Liu, Yong
FRONTIERS IN IMMUNOLOGY, 2025, 16

← 1 2 3 4 5 →