Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility

被引：12

作者：

Ben Chaaben, Arij ^{[1
,2
,3
]}

Mariaselvam, Christina ^{[2
]}

Salah, Sofiane ^{[2
]}

Busson, Marc ^{[2
]}

Dulphy, Nicolas ^{[2
,4
]}

Douik, Hayet ^{[1
]}

Ghanem, Abderraouf ^{[1
]}

Boukaouci, Wahid ^{[2
]}

Al Daccak, Reem ^{[2
]}

Mamoghli, Tesnim ^{[1
]}

Harzallah, Latifa ^{[1
]}

Bouassida, Jihene ^{[1
]}

Fortier, Catherine ^{[4
]}

Gritli, Said ^{[1
]}

Ben Hamida, Jeannette

Charron, Dominique ^{[2
,4
]}

Krishnamoorthy, Rajagopal ^{[2
]}

Guemira, Fethi ^{[1
]}

Tamouza, Ryad ^{[2
,4
]}

机构：

[1] Salah Azaiz Inst Canc, Dept Biol Clin, Tunis, Tunisia

[2] St Louis Hosp, INSERM, U940, Paris, France

[3] Sci Univ Tunis, ISBAT, Dept Biochem, Tunis, Tunisia

[4] St Louis Hosp, Jean Dausset Dept Immunol & Immunogenet & LabEx T, Paris, France

来源：

IMMUNOBIOLOGY | 2015年 / 220卷 / 01期

关键词：

Nasopharyngeal carcinoma; Oxidative stress; Nitric oxide; Nitric oxide synthase; Glutathione S-transferases; Polymorphism; Tunisia; NITRIC-OXIDE SYNTHASE; COLORECTAL-CANCER RISK; DNA-DAMAGE; CROSS-TALK; MYOCARDIAL-INFARCTION; GLU298ASP VARIANT; PROSTATE-CANCER; S TRANSFERASES; BREAST-CANCER; EXPRESSION;

D O I：

10.1016/j.imbio.2014.09.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factor. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3-786C allele and -786 CC genotype, NOS3+894T allele and +894 GT+1T genotypes, NOS2-277 G allele and -277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red-ox stress pathway could augment the risk in NPC-susceptible individuals. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：20 / 25

页数：6

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