Non-Vitamin K Antagonist Oral Anticoagulant Use in Patients With Atrial Fibrillation and Associated Intracranial Hemorrhage: A Focused Review

被引：7

作者：

Arbit, Boris ^{[1
]}

Hsu, Jonathan C. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Cardiol, Cardiac Electrophysiol Sect, La Jolla, CA 92093 USA

来源：

CLINICAL CARDIOLOGY | 2015年 / 38卷 / 11期

关键词：

PROTHROMBIN COMPLEX CONCENTRATE; DIRECT THROMBIN INHIBITOR; ACUTE ISCHEMIC-STROKE; PARTIAL THROMBOPLASTIN TIME; RECOMBINANT FACTOR VIIA; FACTOR XA INHIBITOR; DABIGATRAN ETEXILATE; IN-VITRO; LABORATORY MEASUREMENT; COAGULATION ASSAYS;

D O I：

10.1002/clc.22434

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) is the most common cardiac arrhythmia and predisposes patients to an increased risk of embolic stroke. After nearly 60 years, warfarin is no longer the only effective therapeutic option for patients with AF. Large randomized trials have consistently shown that non- vitamin K oral anticoagulants (NOACs) including dabigatran, rivaroxaban, apixaban, and edoxaban significantly reduce from the risk of intracranial hemorrhage (ICH) compared with warfarin. We provide a focused review regarding the NOACs and ICH in AF patients by summarizing findings of these large clinical trials, mechanisms of lower ICH, reversal strategies with specific agents, and monitoring strategies.

引用

页码：684 / 691

页数：8

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