Cobalt-Catalyzed Markovnikov-Type Selective Hydroboration of Terminal Alkynes

被引：56
作者：
Chen, Jieping [1 ]
Shen, Xuzhong [1 ]
Lu, Zhan [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 02期
关键词：
branched alkenyl boronates; cobalt catalysis; hydroboration; metal hydride species; terminal alkynes; STEREODIVERGENT SYNTHESIS; TRANS-HYDROBORATION; INTERNAL ALKYNES; VINYL; BORYLATION; COMPLEXES; ALKENES; ESTERS; REGIO; IRON;
D O I：
10.1002/anie.202012164
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A cobalt-catalyzed Markovnikov-type hydroboration of terminal alkynes with HBpin to access alpha-alkenyl boronates with good regioselectivity and atom economy is reported. A new ligand has been developed for the cobalt hydride catalyst that has been used for a unique Markovnikov selective insertion of terminal alkynes into metal hydride bond. This operationally simple protocol exhibits excellent functional group tolerance to deliver valuable alkene derivatives.
引用
收藏
页码：690 / 694
页数：5
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