Cobalt-Catalyzed Markovnikov-Type Selective Hydroboration of Terminal Alkynes

被引：61

作者：

Chen, Jieping ^{[1
]}

Shen, Xuzhong ^{[1
]}

Lu, Zhan ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 02期

关键词：

branched alkenyl boronates; cobalt catalysis; hydroboration; metal hydride species; terminal alkynes; STEREODIVERGENT SYNTHESIS; TRANS-HYDROBORATION; INTERNAL ALKYNES; VINYL; BORYLATION; COMPLEXES; ALKENES; ESTERS; REGIO; IRON;

D O I：

10.1002/anie.202012164

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cobalt-catalyzed Markovnikov-type hydroboration of terminal alkynes with HBpin to access alpha-alkenyl boronates with good regioselectivity and atom economy is reported. A new ligand has been developed for the cobalt hydride catalyst that has been used for a unique Markovnikov selective insertion of terminal alkynes into metal hydride bond. This operationally simple protocol exhibits excellent functional group tolerance to deliver valuable alkene derivatives.

引用

页码：690 / 694

页数：5

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