Perspectives on the Trypanosoma cruzi-host cell receptor interactions

被引：29

作者：

Villalta, Fernando ^{[3
]}

Scharfstein, Julio ^{[2
]}

Ashton, Anthony W. ^{[1
,6
]}

Tyler, Kevin M. ^{[7
]}

Guan, Fangxia ^{[4
]}

Mukherjee, Shankar ^{[1
]}

Lima, Maria F. ^{[3
]}

Alvarez, Sandra ^{[1
]}

Weiss, Louis M. ^{[1
]}

Huang, Huan ^{[1
]}

Machado, Fabiana S. ^{[5
]}

Tanowitz, Herbert B. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

[2] Univ Fed Rio de Janeiro, Dept Immunobiol, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, Brazil

[3] Meharry Med Coll, Dept Microbial Pathogenesis & Immune Response, Nashville, TN 37208 USA

[4] Zhengzhou Univ, Dept Bioengn, Zhengzhou, Peoples R China

[5] Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil

[6] Univ Sydney, Div Perinatal Res, Kolling Inst Med Res, Sydney, NSW 2006, Australia

[7] Univ E Anglia, Biomed Res Ctr, Sch Med Hlth Policy & Practice, Norwich NR4 7TJ, Norfolk, England

来源：

PARASITOLOGY RESEARCH | 2009年 / 104卷 / 06期

关键词：

STAGE-SPECIFIC EPITOPE; TRANS-SIALIDASE; DENDRITIC CELLS; CHAGAS-DISEASE; PROLYL OLIGOPEPTIDASE; SURFACE GLYCOPROTEIN; PGE(2) INVOLVEMENT; CRYSTAL-STRUCTURE; MAMMALIAN-CELLS; BINDING PROTEIN;

D O I：

10.1007/s00436-009-1383-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.

引用

页码：1251 / 1260

页数：10

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