The effect of metal-doped TiO2 nanoparticles on zebrafish embryogenesis

被引：19

作者：

Park, Hyung-Geun ^{[1
,2
]}

Kim, Jung In ^{[1
,2
]}

Kang, Misook ^{[3
]}

Yeo, Min-Kyeong ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Coll Engn, Dept Environm Sci, Yongin 446701, Gyeonggi Do, South Korea

[2] Kyung Hee Univ, Coll Engn, Environm Res Ctr, Yongin 446701, Gyeonggi Do, South Korea

[3] Yeungnam Univ, Coll Sci, Dept Chem, Kyongsan 712749, Gyeongbuk, South Korea

来源：

MOLECULAR & CELLULAR TOXICOLOGY | 2014年 / 10卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Metal-doped TiO2 nanoparticles; Photocatalysis; Energy efficiency; Toxicity; Zebrafish embryos; HYDROGEN-PRODUCTION; OXIDATIVE STRESS; TOXICITY; DEGRADATION; PHOTOCATALYST; PERFORMANCE; MECHANISM; EXPOSURE; NANO; ZNO;

D O I：

10.1007/s13273-014-0033-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we manufactured metal-doped TiO2 nanoparticles using several transition metals (Mn, Fe, Ni, and Cu). Their physicochemical properties were evaluated by transmission electron microscopy (TEM), X-ray diffiaction (XRD) analysis, and UV-visible spectra. The energy efficiency of the metals increased in the order of Ni- < Cu- < Mn- < Fe-TiO2. For toxicity testing, zebrafish embryos were exposed to 4 mg L-1 of metal-doped TiO2 nanoparticles. We determined the survival rate (%) and abnormal morphology rate (%) of the exposed embryos and also observed apoptosis and necrosis using confocal microscopy. The metal TiO2 nanoparticles showed acute toxicity in the order of Mn- < Cu- < Ni- <= Fe-TiO2. Although the Fe-TiO2 NPs group demonstrated the highest photocatalytic performance, it also exhibited the highest toxic effects. Among the metals, the Mn-TiO2 NPs group demonstrated improved photocatalysis compared to the other samples except for the Fe-TiO2 NPs along with the lowest toxic effects. For these reasons, the most suitable doping metal was the Mn-TiO2 NPs group considering its energy activity and environmental impacts.

引用

页码：293 / 301

页数：9

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