A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate

被引：15

作者：

Filipovic, Nenad R. ^{[1
]}

Markovic, Ivanka ^{[2
]}

Mitic, Dragana ^{[3
]}

Polovic, Natalija ^{[3
]}

Milcic, Milos ^{[3
]}

Dulovic, Marija ^{[2
]}

Jovanovic, Maja ^{[2
]}

Savic, Milena ^{[1
]}

Niksic, Miomir ^{[1
]}

Andelkovic, Katarina ^{[3
]}

Todorovic, Tamara ^{[3
]}

机构：

[1] Univ Belgrade, Fac Agr, Dept Chem & Biochem, Belgrade, Serbia

[2] Univ Belgrade, Fac Med, Inst Med & Clin Biochem, Belgrade, Serbia

[3] Univ Belgrade, Fac Chem, Belgrade, Serbia

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2014年 / 28卷 / 03期

关键词：

N-heteroaromatic Schiff Base; Zinc; Cytotoxic Activity; Apoptosis; Oxidative Stress; X-RAY-STRUCTURE; METAL-COMPLEXES; COPPER(II) COMPLEXES; DNA-DAMAGE; VITAMIN-C; ZINC; ACID; SEMICARBAZONES; ANTIBACTERIAL; COBALT(III);

D O I：

10.1002/jbt.21541

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation.

引用

页码：99 / 110

页数：12

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