The ABCs of centromeres

被引：14

作者：

Mellone, B ^{[1
]}

Erhardt, S

Karpen, GH

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Dept Genome Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 05期

关键词：

D O I：

10.1038/ncb0506-427

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accurate segregation of genetic information during cell division relies on a multiprotein complex called the kinetochore, whose formation requires specialized centromeric chromatin. Two papers in this issue of Nature Cell Biology identify a multitude of new vertebrate kinetochore proteins that provide insight into the link between centromeric chromatin and the kinetochore, and suggest a functional relationship between centromeres and nucleoli during interphase.

引用

页码：427 / 429

页数：3

共 16 条

[1] Conserved organization of centromeric chromatin in flies and humans [J].

Blower, MD ;

Sullivan, BA ;

Karpen, GH .

DEVELOPMENTAL CELL, 2002, 2 (03) :319-330

[2] A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast [J].

Chen, ES ;

Saitoh, S ;

Yanagida, M ;

Takahashi, K .

MOLECULAR CELL, 2003, 11 (01) :175-187

[3] Centromeres and kinetochores: From epigenetics to mitotic checkpoint signaling [J].

Cleveland, DW ;

Mao, YH ;

Sullivan, KF .

CELL, 2003, 112 (04) :407-421

[4] The human CENP-A centromeric nucleosome-associated complex [J].

Foltz, DR ;

Jansen, LET ;

Black, BE ;

Bailey, AO ;

Yates, JR ;

Cleveland, DW .

NATURE CELL BIOLOGY, 2006, 8 (05) :458-U77

[5] Stretching it: putting the CEN(P-A) in centromere [J].

Mellone, BG ;

Allshire, RC .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (02) :191-198

[6] CENP-I is essential for centromere function in vertebrate cells [J].

Nishihashi, A ;

Haraguchi, T ;

Hiraoka, Y ;

Ikemura, T ;

Regnier, V ;

Dodson, H ;

Earnshaw, WC ;

Fukagawa, T .

DEVELOPMENTAL CELL, 2002, 2 (04) :463-476

[7] Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase [J].

Obuse, C ;

Yang, H ;

Nozaki, N ;

Goto, SH ;

Okazaki, T ;

Yoda, K .

GENES TO CELLS, 2004, 9 (02) :105-120

[8] CENTROMERE AUTOANTIGENS ARE ASSOCIATED WITH THE NUCLEOLUS [J].

OCHS, RL ;

PRESS, RI .

EXPERIMENTAL CELL RESEARCH, 1992, 200 (02) :339-350

[9] The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres [J].

Okada, M ;

Cheeseman, IM ;

Hori, T ;

Okawa, K ;

McLeod, IX ;

Yates, JR ;

Desai, A ;

Fukagawa, T .

NATURE CELL BIOLOGY, 2006, 8 (05) :446-U61

[10] Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator [J].

Pluta, AF ;

Earnshaw, WC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18767-18774

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