Allopurinol and the risk of ventricular arrhythmias in the elderly: a study using US Medicare data

被引:10
作者
Singh, Jasvinder A. [1 ,2 ,3 ,4 ,5 ]
Cleveland, John [2 ,3 ,5 ]
机构
[1] Birmingham VA Med Ctr, Med Serv, Birmingham, AL 35233 USA
[2] UAB, Sch Med, Dept Med, Birmingham, AL 35294 USA
[3] UAB, Div Epidemiol, Sch Publ Hlth, Birmingham, AL 35294 USA
[4] Mayo Clin, Coll Med, Dept Orthoped Surg, Rochester, MN USA
[5] Univ Alabama Birmingham, Fac Off Tower 805B,510 20th St S, Birmingham, AL 35294 USA
来源
BMC MEDICINE | 2017年 / 15卷
关键词
Allopurinol; Ventricular arrhythmias; Risk factor; Elderly; Medicare; XANTHINE-OXIDASE INHIBITION; SUDDEN CARDIAC DEATH; REPERFUSION-INDUCED ARRHYTHMIAS; MYOCARDIAL-INFARCTION; ATRIAL-FIBRILLATION; CARDIOVASCULAR-DISEASE; RACIAL-DIFFERENCES; EUROPEAN-SOCIETY; BLOOD-PRESSURE; OLDER-ADULTS;
D O I
10.1186/s12916-017-0816-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: There are no published human studies investigating whether the use of allopurinol, the most commonly used medication for the treatment of hyperuricemia in gout, the most common type of inflammatory arthritis in adults, has any beneficial effects on ventricular electrophysiology. The objective of our study was to assess whether allopurinol use is associated with a reduction in the risk of ventricular arrhythmias (VA). Methods: We used the 5% random sample of Medicare beneficiaries from 2006-2012 to examine new allopurinol use and the risk of incident VA. Multivariable Cox regression analyses were adjusted for demographics (age, race, sex), comorbidity, cardiac medications, and conditions associated with VA. We calculated hazard ratios (HR) and 95% confidence intervals (CI). Results: Of the 28,755 episodes of new allopurinol use, 2538 were associated with incident VA (8.8%). Among patients with incident VA, 54% were male, 78% were White, 75% had gout as the underlying diagnosis, and the mean Charlson-Romano comorbidity score was 4.8. The crude incidence of VA per 1,000,000 person-days declined as the duration of allopurinol use increased: 1-180 days, 151; 181 days to 2 years, 105; and > 2 years, 85. In multivariableadjusted analyses, compared to non-use, allopurinol use was associated with lower HR of VA of 0.82 (95% CI, 0.76-0.90). Compared to allopurinol non-use, longer allopurinol use durations were significantly associated with lower multivariable-adjusted HR for VA: 1-180 days, 0.96 (95% CI, 0.85-1.08); 181 days to 2 years, 0.76 (95% CI, 0.68-0.85); and > 2 years, 0.72 (95% CI, 0.60-0.87). Multiple sensitivity analyses adjusting for cardiac conditions, anti-arrhythmic drugs and alternate definitions confirmed our findings with minimal/no attenuation of estimates. Conclusion: Allopurinol use and use duration of more than 6 months were independently associated with a lower risk of VA. Future studies need to assess the pathophysiology of this potential benefit.
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页数:11
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