Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe - An ECCO-EpiCom study

被引：74

作者：

Burisch, J. ^{[1
]}

Pedersen, N. ^{[1
]}

Cukovic-Cavka, S. ^{[2
]}

Turk, N. ^{[2
]}

Kaimakliotis, I. ^{[3
]}

Duricova, D. ^{[4
]}

Bortlik, M. ^{[4
]}

Shonova, O. ^{[5
]}

Vind, I. ^{[6
]}

Avnstrom, S. ^{[6
]}

Thorsgaard, N. ^{[7
]}

Krabbe, S. ^{[8
]}

Andersen, V. ^{[8
,9
,10
]}

Dahlerup, J. F. ^{[11
]}

Kjeldsen, J. ^{[12
]}

Salupere, R.

Olsen, J. ^{[13
,14
]}

Nielsen, K. R. ^{[14
]}

Manninen, P. ^{[15
]}

Collin, P. ^{[15
]}

Katsanos, K. H. ^{[16
,17
]}

Tsianos, E. V. ^{[16
,17
]}

Ladefoged, K. ^{[18
]}

Lakatos, L. ^{[19
]}

Ragnarsson, G. ^{[20
]}

Bjornsson, E. ^{[20
]}

Bailey, Y. ^{[21
]}

O'Morain, C. ^{[21
]}

Schwartz, D. ^{[22
,23
]}

Odes, S. ^{[22
,23
]}

Giannotta, M. ^{[24
]}

Girardin, G. ^{[25
]}

Kiudelis, G. ^{[26
]}

Kupcinskas, L. ^{[26
]}

Turcan, S. ^{[27
]}

Barros, L. ^{[28
]}

Magro, F. ^{[29
,30
,31
]}

Lazar, D. ^{[32
]}

Goldis, A. ^{[32
]}

Nikulina, I. ^{[33
]}

Belousova, E. ^{[33
]}

Martinez-Ares, D. ^{[34
]}

Hernandez, V. ^{[34
]}

Almer, S. ^{[35
,36
]}

Zhulina, Y. ^{[37
]}

Halfvarson, J. ^{[37
,38
]}

Arebi, N. ^{[39
]}

Tsai, H. H. ^{[40
]}

Sebastian, S. ^{[40
]}

Lakatos, P. L. ^{[19
]}

机构：

[1] Herlev Univ Hosp, Med Sect, Ctr Digest Dis, DK-2730 Copenhagen, Denmark

[2] Univ Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Zagreb 41001, Croatia

[3] Nicosia Private Practice, Nicosia, Cyprus

[4] Charles Univ Prague, IBD Ctr ISCARE, Prague, Czech Republic

[5] Hosp Ceske Budejovice, Dept Gastroenterol, Ceske Budejovice, Czech Republic

[6] Amager Hosp, Dept Med, Amager, Denmark

[7] Herning Cent Hosp, Dept Med, Herning, Denmark

[8] Viborg Reg Hosp, Dept Med, Viborg, Denmark

[9] Hosp Southern Jutland, Organ Ctr, Aabenraa, Denmark

[10] Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark

[11] Aarhus Univ Hosp, Dept Med Hepatol & Gastroenterol 5, Aarhus, Denmark

[12] Odense Univ Hosp, Dept Med Gastroenterol, DK-5000 Odense, Denmark

[13] Tartu Univ Hosp, Div Gastroenterol & Endocrinol, Tartu, Estonia

[14] Natl Hosp Faroe Islands, Dept Med, Torshavn, Faroe Islands, Denmark

[15] Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland

[16] Univ Hosp, Div Internal Med 1, Ioannina, Greece

[17] Univ Hosp, Hepatogastroenterol Unit, Ioannina, Greece

[18] Dronning Ingrids Hosp, Dept Med, Nuuk, Greenland

[19] Semmelweis Univ, Dept Med 1, H-1085 Budapest, Hungary

[20] Natl Univ Hosp Reykjavik, Sect Gastroenterol & Hepatol, Dept Internal Med, Reykjavik, Iceland

[21] Adelaide & Meath Hosp, Dept Gastroenterol, TCD, Dublin, Ireland

[22] Soroka Med Ctr, Dept Gastroenterol & Hepatol, IL-84101 Beer Sheva, Israel

[23] Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel

[24] Careggi Hosp, Gastroenterol Unit, Florence, Italy

[25] Azienda Osped Univ Padova, UO Gastroenterol, Padua, Italy

[26] Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania

[27] State Univ Med & Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova

[28] Hosp de Vale de Sousa, Oporto, Portugal

[29] Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal

[30] Oporto Med Sch, Inst Pharmacol & Therapeut, Oporto, Portugal

[31] Univ Porto, Inst Mol & Cell Biol, P-4100 Oporto, Portugal

[32] Univ Med Victor Babes, Gastroenterol Clin, Timisoara, Romania

[33] Moscow Reg Res Clin Inst, Dept Gastroenterol, Moscow, Russia

[34] Complexo Hosp Univ Vigo, Dept Gastroenterol, Vigo, Spain

[35] Karolinska Inst, Div Gastroenterol & Hepatol, Stockholm, Sweden

[36] Cty Council Ostergotland, Dept Gastroenterol UHL, Linkoping, Sweden

[37] Orebro Univ Hosp, Div Gastroenterol, Dept Med, Orebro, Sweden

[38] Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden

[39] Univ London Imperial Coll Sci Technol & Med, St Marks Hosp, London, England

[40] Hull Royal Infirm, Hull & York Med Sch, Hull & East Yorkshire NHS Trust, Kingston Upon Hull HU3 2JZ, N Humberside, England

[41] Gentofte Univ Hosp, Dept Med Gastroenterol, Copenhagen, Denmark

来源：

JOURNAL OF CROHNS & COLITIS | 2014年 / 8卷 / 07期

关键词：

Environmental factors; Population-based; Inception cohort; Inflammatory bowel disease; ORAL-CONTRACEPTIVE USE; CROHNS-DISEASE; ULCERATIVE-COLITIS; NUTRITIONAL-STATUS; EASTERN-EUROPE; DIETARY-INTAKE; RISK-FACTORS; MODERN LIFE; APPENDECTOMY; SMOKING;

D O I：

10.1016/j.crohns.2013.11.021

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and Aims: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of Living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients. Methods: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1 million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors. Results: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p < 0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p < 0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p < 0.01). Conclusions: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle. (C) 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

引用

页码：607 / 616

页数：10

共 58 条

[31]

Lakatos L, 2004, WORLD J GASTROENTERO, V10, P404

[32] Dietary intake and nutritional status of children and adolescents in Europe [J].

Lambert, J ;

Agostoni, C ;

Elmadfa, I ;

Hulshof, K ;

Krause, E ;

Livingstone, B ;

Socha, P ;

Pannemans, D ;

Samartín, S .

BRITISH JOURNAL OF NUTRITION, 2004, 92 :S147-S211

[33]

Langholz E, 1999, DAN MED BULL, V46, P400

[34] Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences [J].

Loftus, EV .

GASTROENTEROLOGY, 2004, 126 (06) :1504-1517

[35] Smoking and inflammatory bowel disease: A meta-analysis [J].

Mahid, Suhal S. ;

Minor, Kyle S. ;

Soto, Roberto E. ;

Hornung, Carlton A. ;

Galandiuk, Susan .

MAYO CLINIC PROCEEDINGS, 2006, 81 (11) :1462-1471

[36]

Martinez-Medina M, 2013, W DIET INDUCES DYSBI

[37] The effect of acute psychologic stress on systemic and rectal mucosal measures of inflammation in ulcerative colitis [J].

Mawdsley, Joel E. ;

Macey, Marion G. ;

Feakins, Roger M. ;

Langmead, Louise ;

Rampton, David S. .

GASTROENTEROLOGY, 2006, 131 (02) :410-419

[38] Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review [J].

Molodecky, Natalie A. ;

Soon, Ing Shian ;

Rabi, Doreen M. ;

Ghali, William A. ;

Ferris, Mollie ;

Chernoff, Greg ;

Benchimol, Eric I. ;

Panaccione, Remo ;

Ghosh, Subrata ;

Barkema, Herman W. ;

Kaplan, Gilaad G. .

GASTROENTEROLOGY, 2012, 142 (01) :46-54

[39]

Munkholm P, 1997, DAN MED BULL, V44, P287

[40] Dietary habits and nutritional status in adolescents in Central and Eastern Europe [J].

Parízková, J .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2000, 54 (Suppl 1) :S36-S40

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