One-Pot Synthesis of α-Carbolines via Sequential Palladium-Catalyzed Aryl Amination and Intramolecular Arylation

被引：66

作者：

Laha, Joydev K.

Petrou, Philip

Cuny, Gregory D. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Harvard NeuroDiscovery Ctr, Lab Drug Discovery Neurodegenerat, Cambridge, MA 02139 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 08期

关键词：

TOPOISOMERASE-II INHIBITORS; GAMMA-CARBOLINE; RING-SYSTEM; DERIVATIVES; PYRIDO<2,3-B>INDOLES; GROSSULARINE-1; STRATEGY;

D O I：

10.1021/jo802776m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot synthesis of alpha-carbolines via a palladium-catalyzed aryl amination followed by intramolecular arylation is described. 2,3-Dichloro- and 2,3-dibromopyridines have been shown to react with readily available anilines to obtain various substituted alpha-carbolines in moderate to excellent yields.

引用

页码：3152 / 3155

页数：4

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