Glutamate and GABA-Metabolizing Enzymes in Post-mortem Cerebellum in Alzheimer's Disease: Phosphate-Activated Glutaminase and Glutamic Acid Decarboxylase

被引：29

作者：

Burbaeva, G. Sh ^{[1
]}

Boksha, I. S. ^{[2
]}

Tereshkina, E. B. ^{[1
]}

Savushkina, O. K. ^{[1
]}

Prokhorova, T. A. ^{[1
]}

Vorobyeva, E. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 115522, Russia

[2] Russian Acad Med Sci, Mental Hlth Res Ctr, Lab Neurochem, Moscow 117152, Russia

来源：

CEREBELLUM | 2014年 / 13卷 / 05期

关键词：

Phosphate-activated glutaminase; Glutamic acid decarboxylase; GABA metabolism; Glutamate metabolism; Alzheimer's disease; Autopsied cerebellum; GAMMA-AMINOBUTYRIC-ACID; GABAERGIC NEURONS; PREFRONTAL CORTEX; 67-KDA ISOFORM; MICE LACKING; FORMS; BRAIN; LOCALIZATION; GAD67; TRANSMITTER;

D O I：

10.1007/s12311-014-0573-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Enzymes of glutamate and GABA metabolism in postmortem cerebellum from patients with Alzheimer's disease (AD) have not been comprehensively studied. The present work reports results of original comparative study on levels of phosphate-activated glutaminase (PAG) and glutamic acid decarboxylase isoenzymes (GAD65/67) in autopsied cerebellum samples from AD patients and matched controls (13 cases in each group) as well as summarizes published evidence for altered levels of PAG and GAD65/67 in AD brain. Altered (decreased) levels of these enzymes and changes in links between amounts of these enzymes and other glutamate-metabolizing enzymes (such as glutamate dehydrogenase and glutamine synthetase-like protein) in AD cerebella suggest significantly impaired glutamate and GABA metabolism in this brain region, which was previously regarded as not substantially involved in AD pathogenesis.

引用

页码：607 / 615

页数：9

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