Aluminum and Silica in Drinking Water and the Risk of Alzheimer's Disease or Cognitive Decline: Findings From 15-Year Follow-up of the PAQUID Cohort

被引:227
作者
Rondeau, Virginie [1 ,2 ]
Jacqmin-Gadda, Helene [1 ,2 ]
Commenges, Daniel [1 ,2 ]
Helmer, Catherine [2 ,3 ]
Dartigues, Jean-Francois [2 ,3 ]
机构
[1] INSERM, Unite 897, Div Biostat, F-33076 Bordeaux, France
[2] Univ Victor Segalen Bordeaux 2, Bordeaux, France
[3] INSERM, Unite 897, Div Epidemiol Publ Hlth & Dev, F-33076 Bordeaux, France
关键词
aluminum; Alzheimer disease; cognition; dementia; silicon dioxide; water; water supply; DEMENTIA; PROGRAM;
D O I
10.1093/aje/kwn348
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The authors examined associations between exposure to aluminum or silica from drinking water and risk of cognitive decline, dementia, and Alzheimer's disease among elderly subjects followed for 15 years (1988-2003). They actively searched for incident cases of dementia among persons aged 65 years or over living in 91 civil drinking-water areas in southern France. Two measures of exposure to aluminum were assessed: geographic exposure and individual exposure, taking into account daily consumption of tap water and bottled water. A total of 1,925 subjects who were free of dementia at baseline and had reliable water assessment data were analyzed. Using random-effects models, the authors found that cognitive decline with time was greater in subjects with a higher daily intake of aluminum from drinking water (>= 0.1 mg/day, P = 0.005) or higher geographic exposure to aluminum. Using a Cox model, a high daily intake of aluminum was significantly associated with increased risk of dementia. Conversely, an increase of 10 mg/day in silica intake was associated with a reduced risk of dementia (adjusted relative risk = 0.89, P = 0.036). However, geographic exposure to aluminum or silica from tap water was not associated with dementia. High consumption of aluminum from drinking water may be a risk factor for Alzheimer's disease.
引用
收藏
页码:489 / 496
页数:8
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