PharmGKB: A worldwide resource for pharmacogenomic information

被引：253

作者：

Barbarino, Julia M. ^{[1
]}

Whirl-Carrillo, Michelle ^{[1
]}

Altman, Russ B. ^{[2
,3
]}

Klein, Teri E. ^{[1
,4
]}

机构：

[1] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Biomed Engn, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Med, Stanford, CA 94305 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE | 2018年 / 10卷 / 04期

关键词：

pharmacodynamics; pharmacogenetics; pharmacogenomics; pharmacokinetics; pharmGKB; IMPLEMENTATION CONSORTIUM GUIDELINES; THIOPURINE METHYLTRANSFERASE GENOTYPE; CLINICAL PHARMACOGENETICS; DRUG HYPERSENSITIVITY; PEPTIDE REPERTOIRE; HLA; UPDATE; HLA-B-ASTERISK-57/01; NETWORK; PATHWAY;

D O I：

10.1002/wsbm.1417

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

As precision medicine becomes increasingly relevant in healthcare, the field of pharmacogenomics (PGx) also continues to gain prominence in the clinical setting. Leading institutions have begun to implement PGx testing and the amount of published PGx literature increases yearly. The Pharmacogenomics Knowledgebase (PharmGKB; ) is one of the foremost worldwide resources for PGx knowledge, and the organization has been adapting and refocusing its mission along with the current revolution in genomic medicine. The PharmGKB website provides a diverse array of PGx information, from annotations of the primary literature to guidelines for adjusting drug treatment based on genetic information. It is freely available and accessible to everyone from researchers to clinicians to everyday citizens. PharmGKB was found over 17years ago, but continues to be a vital resource for the entire PGx community and the general public. This article is categorized under: Translational, Genomic, and Systems Medicine > Translational Medicine

引用

页数：13

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