Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

被引：97

作者：

Dalen, P ^{[1
]}

Frengell, C ^{[1
]}

Dahl, ML ^{[1
]}

Sjoqvist, F ^{[1
]}

机构：

[1] HUDDINGE UNIV HOSP,DIV CLIN PHARMACOL,DEPT MED LAB SCI & TECHNOL,S-14186 HUDDINGE,SWEDEN

来源：

THERAPEUTIC DRUG MONITORING | 1997年 / 19卷 / 05期

关键词：

cytochrome; P-450; genetics; metabolism;

D O I：

10.1097/00007691-199710000-00011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The authors describe a 33-year-old woman who experienced severe pain in the epigastrium after codeine intake. This side-effect is consistent with that of morphine. Later, the patient was phenotyped and genotyped as an ultrarapid metabolizer with high capacity to metabolize codeine to morphine.

引用

页码：543 / 544

页数：2

共 11 条

[1] PREVALENCE OF CYP2D6 GENE DUPLICATION AND ITS REPERCUSSION ON THE OXIDATIVE PHENOTYPE IN A WHITE-POPULATION
AGUNDEZ, JAG
LEDESMA, MC
LADERO, JM
BENITEZ, J
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1995, 57 (03) : 265 - 269
[2] Aklillu E, 1996, J PHARMACOL EXP THER, V278, P441
[3] HYDROXYLATION POLYMORPHISMS OF DEBRISOQUINE AND MEPHENYTOIN IN EUROPEAN POPULATIONS
ALVAN, G
BECHTEL, P
ISELIUS, L
GUNDERTREMY, U
[J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1990, 39 (06) : 533 - 537
[4] MOLECULAR-BASIS FOR RATIONAL MEGAPRESCRIBING IN ULTRARAPID HYDROXYLATORS OF DEBRISOQUINE
BERTILSSON, L
DAHL, ML
SJOQVIST, F
ABERGWISTEDT, A
HUMBLE, M
JOHANSSON, I
LUNDQVIST, E
INGELMANSUNDBERG, M
[J]. LANCET, 1993, 341 (8836) : 63 - 63
[5] ANALYSIS OF THE CYP2D6 GENE IN RELATION TO DEBRISOQUIN AND DESIPRAMINE HYDROXYLATION IN A SWEDISH POPULATION
DAHL, ML
JOHANSSON, I
PALMERTZ, MP
INGELMANSUNDBERG, M
SJOQVIST, F
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1992, 51 (01) : 12 - 17
[6] DAHL ML, 1995, J PHARMACOL EXP THER, V274, P516
[7] A FAMILY AND POPULATION STUDY OF THE GENETIC-POLYMORPHISM OF DEBRISOQUINE OXIDATION IN A WHITE BRITISH-POPULATION
EVANS, DAP
MAHGOUB, A
SLOAN, TP
IDLE, JR
SMITH, RL
[J]. JOURNAL OF MEDICAL GENETICS, 1980, 17 (02) : 102 - 105
[8] GENOTYPING OF POOR METABOLIZERS OF DEBRISOQUINE BY ALLELE-SPECIFIC PCR AMPLIFICATION
HEIM, M
MEYER, UA
[J]. LANCET, 1990, 336 (8714) : 529 - 532
[9] INHERITED AMPLIFICATION OF AN ACTIVE GENE IN THE CYTOCHROME-P450 CYP2D LOCUS AS A CAUSE OF ULTRARAPID METABOLISM OF DEBRISOQUINE
JOHANSSON, I
LUNDQVIST, E
BERTILSSON, L
DAHL, ML
SJOQVIST, F
INGELMANSUNDBERG, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11825 - 11829
[10] YUE Q, 1997, THER DRUG MONIT, V19

← 1 2 →