The adenine nucleotide translocator in apoptosis

被引：106
作者：
Belzacq, AS
Vieira, HLA
Kroemer, G
Brenner, C
机构：
[1] Univ Technol Compiegne, CNRS, UMR 6022, F-60205 Compiegne, France
[2] Inst Gustave Roussy, CNRS, UMR 1599, F-94805 Villejuif, France
来源：
BIOCHIMIE | 2002年 / 84卷 / 2-3期
关键词：
ADP/ATP exchange; Bcl-2; liposome; mitochondrion; oncogene; permeability transition;
D O I：
10.1016/S0300-9084(02)01366-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alteration of mitochondrial membrane permeability is a central mechanism leading invariably to cell death, which results, at least in part, from the opening of the permeability transition pore complex (PTPC), Indeed, extended PTPC opening is sufficient to trigger an increase in mitochondrial membrane permeability and apoptosis. Among the various PTPC components. the adenine nucleotide translocator (ANT) appears to act as a bi-functional protein which, on the one hand, contributes to a crucial step of aerobic energy metabolism, the ADP/ATP translocation, and on the other hand, can be converted into a pro-apoptotic pore under the control of onco- and anti-oncoproteins from the Bax/Bcl-2 family. In this review, we will discuss recent advances in the cooperation between ANT and Bax/Bcl-2 family members, the multiplicity of agents affecting ANT pore function and the putative role of ANT isoforms in apoptosis control. (C) 2002 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：167 / 176
页数：10
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