The unnamed complex: what do we know about Smc5-Smc6?

被引：93
作者：
De Piccoli, Giacomo [1 ]
Torres-Rosell, Jordi [1 ]
Aragon, Luis [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Cell Cycle Grp, London W12 0NN, England
来源：
CHROMOSOME RESEARCH | 2009年 / 17卷 / 02期
关键词：
Smc5-Smc6; recombination; replication forks; rDNA; DOUBLE-STRAND BREAKS; STALLED REPLICATION FORKS; SISTER-CHROMATID EXCHANGE; DNA-DAMAGE RESPONSE; SACCHAROMYCES-CEREVISIAE; SCHIZOSACCHAROMYCES-POMBE; SUMO LIGASE; HOMOLOGOUS RECOMBINATION; CHECKPOINT RESPONSES; PROTEIN COMPLEX;
D O I：
10.1007/s10577-008-9016-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structural maintenance of chromosome (SMC) proteins constitute the cores of three protein complexes involved in chromosome metabolism; cohesin, condensin and the Smc5-Smc6 complex. While the roles of cohesin and condensin in sister chromatid cohesion and chromosome condensation respectively have been described, the cellular function of Smc5-Smc6 is as yet not understood, consequently the less descriptive name. The complex is involved in a variety of DNA repair pathways. It contains activities reminiscent of those described for cohesin and condensin, as well as several DNA helicases and endonucleases. It is required for sister chromatid recombination, and smc5-smc6 mutants suffer from the accumulation of unscheduled recombination intermediates. The complex contains a SUMO-ligase and potentially an ubiquitin-ligase; thus Smc5-Smc6 might presently have a dull name, but it seems destined to be recognized as a key player in the maintenance of chromosome stability. In this review we summarize our present understanding of this enigmatic protein complex.
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页码：251 / 263
页数：13
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