OPA1 and PARL keep a lid on apoptosis

被引：48

作者：

Gottlieb, Eyal ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Canc Res UK, Apoptosis & Tumour Physiol Lab, Glasgow G61 1BD, Lanark, Scotland

来源：

CELL | 2006年 / 126卷 / 01期

关键词：

D O I：

10.1016/j.cell.2006.06.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A change in the shape of mitochondrial cristae must take place to attain rapid and complete release of cytochrome c during apoptosis. In this issue of Cell, Cipolat et al. (2006) and Frezza et al. (2006) show that a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1 are critical regulators of cristae remodeling.

引用

收藏

页码：27 / 29

页数：3

相关论文

共 7 条

[1] Dynamin family of mechanoenzymes [J].

Danino, D ;

Hinshaw, JE .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (04) :454-460

[2] The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis [J].

Frank, S ;

Gaume, B ;

Bergmann-Leitner, ES ;

Leitner, WW ;

Robert, EG ;

Catez, F ;

Smith, CL ;

Youle, RJ .

DEVELOPMENTAL CELL, 2001, 1 (04) :515-525

[3] The internal structure of mitochondria [J].

Frey, TG ;

Mannella, CA .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (07) :319-324

[4] Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis [J].

Germain, M ;

Mathai, JP ;

McBride, HM ;

Shore, GC .

EMBO JOURNAL, 2005, 24 (08) :1546-1556

[5] Mitochondrial membrane remodelling regulated by a conserved rhomboid protease [J].

McQuibban, GA ;

Saurya, S ;

Freeman, M .

NATURE, 2003, 423 (6939) :537-541

[6] A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis [J].

Scorrano, L ;

Ashiya, M ;

Buttle, K ;

Weiler, S ;

Oakes, SA ;

Mannella, CA ;

Korsmeyer, SJ .

DEVELOPMENTAL CELL, 2002, 2 (01) :55-67

[7] Mitochondrial fission in apoptosis [J].

Youle, RJ ;

Karbowski, M .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (08) :657-663