Membrane and actin dynamics interplay at lamellipodia leading edge

被引：79

作者：

Bisi, Sara ^{[1
]}

Disanza, Andrea ^{[1
]}

Malinverno, Chiara ^{[1
]}

Frittoli, Emanuela ^{[1
]}

Palamidessi, Andrea ^{[1
]}

Scita, Giorgio ^{[1
,2
]}

机构：

[1] Fdn Ist FIRC Oncol Molecolare, IFOM, I-20139 Milan, Italy

[2] Univ Milan, Dipartimento Med Chirurgia & Odontoiatria, I-20122 Milan, Italy

来源：

CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 05期

基金：

欧洲研究理事会;

关键词：

WAVE REGULATORY COMPLEX; TUMOR-CELL INVASION; ARP2/3; COMPLEX; CAPPING PROTEIN; EXO70; INTERACTS; PLASMA-MEMBRANE; IRSP53; MOTILITY; DOWNSTREAM; PROTRUSION;

D O I：

10.1016/j.ceb.2013.04.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the necessity to impose a tight control on their activity. This is exerted through temporally coordinated and coincident signals which limit the intensity and duration of this activity. In addition, interactions of the WRC and Arp2/3 complexes with membrane binding and surprisingly membrane trafficking proteins is also emerging, revealing the existence of an 'endocytic wiring system' that spatially restrict branched actin elongation for the execution of polarized functions during cell migration.

引用

页码：565 / 573

页数：9

共 83 条

[11] Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases [J].

Choi, J ;

Ko, J ;

Racz, B ;

Burette, A ;

Lee, JR ;

Kim, S ;

Na, M ;

Lee, HW ;

Kim, K ;

Weinberg, RJ ;

Kim, E .

JOURNAL OF NEUROSCIENCE, 2005, 25 (04) :869-879

[12] The serine/threonine kinase Par1 b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signaling [J].

Cohen, David ;

Fernandez, Dawn ;

Lazaro-Dieguez, Francisco ;

Muesch, Anne .

JOURNAL OF CELL BIOLOGY, 2011, 192 (03) :525-540

[13] Cell surface dynamics - how Rho GTPases orchestrate the interplay between the plasma membrane and the cortical cytoskeleton [J].

de Curtis, Ivan ;

Meldolesi, Jacopo .

JOURNAL OF CELL SCIENCE, 2012, 125 (19) :4435-4444

[14] Eps8 controls actin-based motility by capping the barbed ends of actin filaments [J].

Disanza, A ;

Carlier, MF ;

Stradal, TEB ;

Didry, D ;

Frittoli, E ;

Confalonieri, S ;

Croce, A ;

Wehland, J ;

Di Fiore, PP ;

Scita, G .

NATURE CELL BIOLOGY, 2004, 6 (12) :1180-1188

[15] Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement [J].

Disanza, A ;

Steffen, A ;

Hertzog, M ;

Frittoli, E ;

Rottner, K ;

Scita, G .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2005, 62 (09) :955-970

[16] Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex [J].

Disanza, Andrea ;

Mantoani, Sara ;

Hertzog, Maud ;

Gerboth, Silke ;

Frittoli, Emanuela ;

Steffen, Anika ;

Berhoerster, Kerstin ;

Kreienkamp, Hans-Juergen ;

Milanesi, Francesca ;

Di Fiore, Pier Paolo ;

Ciliberto, Andrea ;

Stradal, Theresia E. B. ;

Scita, Giorgio .

NATURE CELL BIOLOGY, 2006, 8 (12) :1337-U15

[17] ARF family G proteins and their regulators: roles in membrane transport, development and disease [J].

Donaldson, Julie G. ;

Jackson, Catherine L. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (06) :362-375

[18] Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck [J].

Eden, S ;

Rohatgi, R ;

Podtelejnikov, AV ;

Mann, M ;

Kirschner, MW .

NATURE, 2002, 418 (6899) :790-793

[19] New dimensions in cell migration [J].

Friedl, Peter ;

Sahai, Erik ;

Weiss, Stephen ;

Yamada, Kenneth M. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (11) :743-747

[20] Plasticity of cell migration: a multiscale tuning model [J].

Friedl, Peter ;

Wolf, Katarina .

JOURNAL OF CELL BIOLOGY, 2010, 188 (01) :11-19

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