Membrane and actin dynamics interplay at lamellipodia leading edge

被引：79
作者：
Bisi, Sara [1 ]
Disanza, Andrea [1 ]
Malinverno, Chiara [1 ]
Frittoli, Emanuela [1 ]
Palamidessi, Andrea [1 ]
Scita, Giorgio [1 ,2 ]
机构：
[1] Fdn Ist FIRC Oncol Molecolare, IFOM, I-20139 Milan, Italy
[2] Univ Milan, Dipartimento Med Chirurgia & Odontoiatria, I-20122 Milan, Italy
来源：
CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 05期
基金：
欧洲研究理事会;
关键词：
WAVE REGULATORY COMPLEX; TUMOR-CELL INVASION; ARP2/3; COMPLEX; CAPPING PROTEIN; EXO70; INTERACTS; PLASMA-MEMBRANE; IRSP53; MOTILITY; DOWNSTREAM; PROTRUSION;
D O I：
10.1016/j.ceb.2013.04.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the necessity to impose a tight control on their activity. This is exerted through temporally coordinated and coincident signals which limit the intensity and duration of this activity. In addition, interactions of the WRC and Arp2/3 complexes with membrane binding and surprisingly membrane trafficking proteins is also emerging, revealing the existence of an 'endocytic wiring system' that spatially restrict branched actin elongation for the execution of polarized functions during cell migration.
引用
收藏
页码：565 / 573
页数：9
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